Monoclonal antibody Ki-67 defined growth fraction in benign prostatic hyperplasia and prostatic cancer.

The Journal of Urology
M P GalleeT H Van der Kwast

Abstract

Growth fractions were assessed immunohistochemically in prostatic tissues with benign glandular hyperplasia (BPH) and in specimens of prostatic cancer using the monoclonal antibody Ki-67. This antibody is specific for a proliferation-associated nuclear antigen. In BPH tissues about 0.3% of nuclei of epithelial cells was reactive with Ki-67. The Ki-67 positive nuclei were distributed equally among the basal and luminal cells of the hyperplastic prostatic acini. In prostatic cancer the Ki-67 defined growth fraction ranged from 0.4% to 9.1% (mean value 2.9%). Cancers with a cribriform growth pattern and tumors composed of solid areas of undifferentiated cancer cells showed the highest growth fraction (average values 4.0%, respectively 7.6%). The investigated four tumors composed of undifferentiated solitary tumor cells with diffuse infiltration of the stroma demonstrated an unexpectedly low growth activity (average 1.2%). In cancers with a glandular growth pattern the Ki-67 defined growth fraction of tumor cells varied from 2.2% to 5%. Compared with other epithelial tumors these values are low, but they are in agreement with the earlier findings on prostatic cancer obtained with 3H-thymidine labeling and bromodeoxyuridine incorpor...Continue Reading

References

Mar 1, 1988·The Journal of Pathology·P A HallA G Stansfeld
Jun 1, 1986·Journal of Clinical Pathology·K C GatterD Y Mason
Sep 1, 1986·Journal of Clinical Pathology·J GerdesH Stein
Oct 1, 1988·The Journal of Pathology·W A RaymondJ S Jose
Dec 1, 1987·Journal of Cellular Physiology·K SasakiM Takahashi
Feb 15, 1985·International Journal of Cancer. Journal International Du Cancer·J Gerdes
Jan 15, 1983·International Journal of Cancer. Journal International Du Cancer·J GerdesH Stein
Jan 1, 1983·The Prostate·G Aumüller

❮ Previous
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Citations

Jan 1, 1991·Urological Research·H TsujihashiT Kurita
Jul 1, 1993·British Journal of Urology·J McLoughlinP D Abel
May 29, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·K R LeiteL H Camara-Lopes
Oct 21, 2004·Cancer·David G BostwickBarry Timms
May 21, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Naoki SegawaYoji Katsuoka
Feb 4, 2014·Virchows Archiv : an International Journal of Pathology·Theodorus H Van der Kwast
Dec 20, 2018·Histopathology·C F KweldamT van der Kwast
Jun 1, 1992·British Journal of Urology·S J ThompsonD E Neal
Nov 1, 1994·The Journal of Pathology·C Limas, S P Frizelle
Jan 30, 2004·Cytopathology : Official Journal of the British Society for Clinical Cytology·A BantisP Athanassiadou
Oct 4, 2011·Diagnostic Cytopathology·Konstantinos KosmasPaulina Athanassiadou
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·A R BotticelliM Migaldi
Jan 1, 1993·Archives of Dermatological Research·H P BaumG Unteregger
Jan 27, 2004·The Prostate·Wolfgang HorningerG Bartsch
Aug 28, 2003·Developmental Biology·Annemarie A DonjacourGerald R Cunha
Jul 1, 1993·Cancer Treatment Reviews·W S Hsieh, J W Simons
Mar 11, 1992·Human Pathology·W C Allsbrook, W W Simms
Jul 1, 1991·Experimental Cell Research·A Thibodeau, M Vincent

❮ Previous
Next ❯

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