Monoclonal antibody to a human germ cell membrane glycoprotein that inhibits fertilization

Science
R K NazM S Hamilton

Abstract

A monoclonal antibody to an antigen in the human germ cell membrane did not agglutinate or immobilize sperm but inhibited binding and penetration of zona-free hamster ova by human sperm and blocked murine fertilization in vitro. The antibody, of the 2a subclass of immunoglobulin G, was germ cell-specific but not species-specific. It recognized a single antigen of 23 kilodaltons that has been isolated from human germ cells. This fertilization antigen, located on the postacrosome , midpiece, and tail of human sperm, is a glycoprotein of testicular origin associated with some types of human involuntary immunoinfertility .

References

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Citations

Dec 1, 1992·Molecular Reproduction and Development·C BruckerG D Hodgen
Aug 31, 2002·Molecular Reproduction and Development·Rajesh K Naz, Xiaolong Zhu
Apr 15, 1986·Experientia·J R BrentjensL Zamboni
Nov 1, 1987·Journal of Reproductive Immunology·A Jassim, H Festenstein
May 1, 1991·Journal of Reproductive Immunology·R K NazE C Yurewicz
Sep 1, 1991·Journal of Reproductive Immunology·H H HandleyC J Flickinger
Sep 1, 1995·Social Science & Medicine·A F Schrater
Dec 4, 2001·Journal of Reproductive Immunology·Rajesh K Naz
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R K NazB B Rosenblum
Oct 1, 1985·The Journal of Cell Biology·L C LopezB D Shur
Oct 1, 1991·International Journal of Andrology·C H YeungT G Cooper
Dec 3, 1999·Immunological Reviews·R K Naz
May 1, 1994·American Journal of Reproductive Immunology : AJRI·P Primakoff
Nov 1, 1987·The Journal of Clinical Investigation·R K Naz
Nov 1, 1993·The Journal of Clinical Investigation·R K NazA C Menge
Mar 12, 2004·Reproductive Biology and Endocrinology : RB&E·Anil Suri
Mar 24, 2004·Reproductive Biology and Endocrinology : RB&E·Alina Domagala, Maciej Kurpisz
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·X Zhu, R K Naz
Jan 1, 1987·Archives of Andrology·Y C YanS S Koide
Dec 1, 1988·American Journal of Obstetrics and Gynecology·R K NazT Fairwell
Aug 1, 1990·American Journal of Obstetrics and Gynecology·R K NazS S Witkin

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