PMID: 6974220Sep 1, 1981Paper

Monoclonal antibody to an IgD allotype induces a new type of allotype suppression in the mouse

The Journal of Experimental Medicine
T TokuhisaL A Herzenberg

Abstract

Studies presented here show that perinatal exposure to anti-IgD allotype antibodies induces a persistant IgG-allotype suppression in the mouse that differs markedly from either the short-term or chronic allotype suppressions induced by antibodies to IgG or IgM allotypes. This novel form of allotype suppression induced by injecting neonatal BALB/c x SJL mice with monoclonal antibody to the paternal Igh-5b (IgD) allotype drastically reduces paternal allotype production during the first 6 mo of the affected animal's life and simultaneously stimulates compensatory production of maternal allotype IgG. In addition, it interferes with the development of B cells carrying the paternal IgD allotype and impairs the development of memory B cells destined to give rise to paternal allotype IgG-producing cells. Thus, its properties make it more like allotype suppression as described in the rabbit than like the known forms of allotype suppression in the mouse. As shown here, Igh-5b-bearing (5b+) B cells are completely depleted from the neonate after anti-5b exposure and only gradually appear as the animal ages. The recovery of the 5b+ population to near normal size (by approximately 14 wk of age) substantially preceeds recovery of the ability ...Continue Reading

References

Oct 1, 1979·The Journal of Experimental Medicine·A YamadaF L Adler
May 1, 1978·European Journal of Immunology·J E LaytonG J Nossal
Jul 1, 1979·The Journal of Experimental Medicine·S J Black, L A Herzenberg
Jan 1, 1979·Immunological Reviews·J A Ledbetter, L A Herzenberg
Jan 1, 1975·Transplantation Reviews·L A HerzenbergC M Metzler
May 1, 1972·The Journal of Experimental Medicine·E B JacobsonL A Herzenberg
Oct 1, 1973·European Journal of Immunology·E B Jacobson
Dec 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·P W KincadeM D Cooper
May 1, 1980·The Journal of Experimental Medicine·L A HerzenbergL A Herzenberg

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Citations

Jan 1, 1982·Annals of the New York Academy of Sciences·G A Leslie, M A Cuchens
Jan 1, 1982·Immunological Reviews·L A HerzenbergL A Herzenberg
Jan 1, 1982·Annals of the New York Academy of Sciences·L A Herzenberg
Oct 1, 1986·Immunological Reviews·L A HerzenbergL A Herzenberg
Apr 1, 1983·Immunology Today·L A Herzenberg
Aug 1, 1986·European Journal of Immunology·P M Wathen, D D Manning
Mar 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bao Hoa DuongDavid Nemazee

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