PMID: 3755142Jun 1, 1986Paper

Monoclonal antibody to macrophages (EMB/11) labels macrophages and microglial cells in human brain

Journal of Clinical Pathology
M M Esiri, J O McGee

Abstract

Normal and diseased human central nervous system (CNS) tissues were studied immunohistochemically by a monoclonal antibody to human macrophages (EBM/11), antisera to glial fibrillary acidic protein (anti-GFAP), and alpha-1-antichymotrypsin (alpha 1-ACT). EBM/11 reacted with brain macrophages located mainly around blood vessels in normal brain; it also reacted with resting microglia in normal brain and with numerous reactive microglia and macrophages in brain tumours and inflammatory lesions. Microglia did not react with anti-GFAP or alpha 1-ACT. An EBM/11 positive phenotype, therefore, is shared by microglia and macrophages and suggests that microglial cells form a specialised part of the mononuclear phagocyte system.

References

Jul 1, 1979·Journal of Neuropathology and Experimental Neurology·G W WoodR A Morantz
Feb 1, 1985·Journal of Clinical Pathology·J M TheakerJ O McGee
Jan 1, 1981·Acta Neuropathologica·Y TsuchihashiS Fujita
Nov 10, 1982·The Journal of Comparative Neurology·J B Brierley, A W Brown

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Citations

Jan 1, 1990·Acta Neuropathologica·I Grundke-IqbalJ G Joshi
Jan 1, 1990·Acta Neuropathologica·J Wegiel, H M Wisniewski
Jan 1, 1987·Acta Neuropathologica·M L RossiD B Brownell
Jan 1, 1996·Acta neurochirurgica·B GiomettoB Tavolato
Apr 1, 1987·Journal of Neurocytology·W J Streit, G W Kreutzberg
Mar 1, 2012·Molecular Neurobiology·Inês Sá-PereiraMaria Alexandra Brito
Aug 1, 1987·Journal of the Neurological Sciences·G M HayesM L Cuzner
Dec 1, 1990·Journal of the Neurological Sciences·M M Esiri, D Gay
Jan 1, 1992·Brain Research. Brain Research Reviews·W E Thomas
Apr 24, 1992·Brain Research. Developmental Brain Research·K D HutchinsW D Lyman
Sep 1, 1988·Journal of Neuroimmunology·G M HayesM L Cuzner
May 1, 1990·Journal of Neuroimmunology·E BlasiF Bistoni
Jun 1, 1988·Trends in Neurosciences·V H Perry, S Gordon
Jan 1, 1988·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J ValatJ Fulcrand
Sep 6, 2003·Journal of Immunological Methods·Karin LundinMats A A Persson
Dec 28, 1999·Brain Research. Brain Research Reviews·W E Thomas
Feb 25, 1998·Brain Research. Developmental Brain Research·N ZecevicM Tosic
Mar 15, 2000·Brain Research Bulletin·H K RuckerW E Thomas
Feb 1, 2013·Pediatric Research·Veena SupramaniamMary Rutherford
Sep 1, 1990·Brain Pathology·M B Graeber, W J Streit
Aug 1, 1987·Journal of Clinical Pathology·C BarbatisJ O McGee
May 1, 1988·Journal of Clinical Pathology·P M KellyJ O McGee
Dec 1, 1989·Journal of Neuroimmunology·C de Micco
Mar 1, 1994·Journal of Neuroimmunology·P J Gebicke-HaerterM Berger
Aug 15, 1998·Annals of the New York Academy of Sciences·L Lorusso, M L Rossi
Feb 4, 2009·Neuropathology and Applied Neurobiology·S GrundA Bornemann
Nov 1, 1987·Neuropathology and Applied Neurobiology·M M Esiri, M C Reading

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