Monoclonal gammopathies and the kidney

Annual Review of Medicine
R A Kyle

Abstract

The major causes of renal insufficiency, present initially in half of the patients with multiple myeloma, are "myeloma kidney" and hypercalcemia. There is no reliable evidence that the isoelectric point (pI) or the type of light chain has an important role in renal failure. Acute renal failure must be treated vigorously with appropriate fluids and electrolytes as well as hemodialysis if necessary. The benefit of plasma exchange has not been proven. Primary systemic amyloidosis or light-chain deposition disease is the usual cause of the nephrotic syndrome in patients with monoclonal gammopathy. The monoclonal gammopathies are a group of disorders that are characterized by the proliferation of plasma cells producing a homogeneous, monoclonal protein (M-protein).

Citations

Jun 27, 1991·The New England Journal of Medicine·A SolomonA A Kattine
Oct 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Chahrazed El HamelMichel Cogné
Nov 1, 1995·The American Journal of Emergency Medicine·W R Triner, M D Birdwell
Jan 25, 2008·Medical Oncology·Natasa ColovićMilica Colović
Mar 10, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·T E ClarkL J Lindsey
Jul 1, 1995·Critical Reviews in Oncology/hematology·E Pascali
Sep 29, 1999·Immunology Today·F J Stevens, Y Argon

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