Monoclonal gammopathy in extranodal marginal zone lymphoma (ENMZL) correlates with advanced disease and bone marrow involvement

American Journal of Hematology
Ekatherine AsatianiBruce D Cheson

Abstract

Monoclonal gammopathy is a well-recognized occurrence in splenic marginal zone lymphoma (MZL); however, its prevalence has never been reported in extranodal MZL (ENMZL). We present results of a retrospective analysis of 26 patients with newly diagnosed as well as previously treated ENMZL. Monoclonal gammopathy was detected in 7 out of 26 (27%) patients. All patients with a monoclonal gammopathy had stage IV disease, and most of them had involvement of lymph nodes and/or bone marrow (n = 6). Only 1 out of 7 patients with a monoclonal spike had stage IV disease diagnosed based on multifocal mucosal involvement. There was also a strong correlation between the involvement of bone marrow and the presence of a monoclonal spike (Fisher's exact test, P = 0.0007). Prevalence of monoclonal gammopathy is higher than previously recognized and indicates advanced disease. However, the prognostic significance of the presence of monoclonal gammopathy in this population is unknown.

References

Sep 30, 1993·The New England Journal of Medicine·UNKNOWN International Non-Hodgkin's Lymphoma Prognostic Factors Project
Jun 22, 2000·Genes, Chromosomes & Cancer·M M OttH K Müller-Hermelink
Nov 17, 2001·American Journal of Clinical Pathology·R ValdezB Schnitzer
Mar 22, 2003·Leukemia Research·T EconomopoulosS Raptis

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Citations

Jun 25, 2013·Annals of Hematology·Boting WuYunfeng Cheng
Oct 16, 2008·Hematology·J M RayaUNKNOWN Hematopathology Canary Islands Working Group
May 16, 2012·American Journal of Clinical Pathology·Khalil M CharafeddineRose T Daher
Oct 20, 2005·Clinical Lymphoma & Myeloma·Robert A Kyle, S Vincent Rajkumar
Nov 13, 2007·Hematology/oncology Clinics of North America·Robert A Kyle, S Vincent Rajkumar
Aug 30, 2006·British Journal of Haematology·Robert A Kyle, S Vincent Rajkumar
Jan 18, 2011·The Korean journal of laboratory medicine·Do Yeun KimSeok Lae Chae
Feb 21, 2019·American Journal of Hematology·Juan Pablo AlderuccioIzidore S Lossos
Nov 30, 2005·American Journal of Hematology·Stefan Wohrer, Markus Raderer
Nov 18, 2006·The Oncologist·Seth M CohenMichael L Grossbard
Nov 18, 2020·British Journal of Haematology·Pablo MozasArmando López-Guillermo
Oct 26, 2020·Hematology/oncology Clinics of North America·Sascha A Tuchman, Jeffrey A Zonder

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