Monoclonal Gammopathy of Renal Significance (MGRS): Prospects for Treatment in Integrated Chinese and Western Medicine.

Chinese Journal of Integrative Medicine
Jin-Pu LiXiang-Rong Rao

Abstract

Monoclonal gammopathy of renal significance (MGRS) is a pathological state which presents with a spectrum of renal lesions. MGRS is characterized by pathogenic monoclonal immunoglobulins or light chains produced by a premalignant plasma cell or B cell clone. In view of inadequate understanding in the past, the low detection rate of MGRS often results in poor outcomes and reduces quality of life of patients. Thus, MGRS stands for a group of clinical refractory renal diseases. To date, no standard treatment strategy for MGRS is available. Current consensus suggests a clone-directed approach that aims to eradicate the offending clone, but its long-term prognosis is not clear. In this article, we discuss the diagnostic methods, highlight treatment advances, and introduce integrated Chinese and Western medicine in the management of MGRS.

References

May 1, 1978·The American Journal of Medicine·R A Kyle
Oct 11, 2012·Blood·Nelson LeungUNKNOWN International Kidney and Monoclonal Gammopathy Research Group
Oct 11, 2013·Blood·Jean-Paul FermandUNKNOWN International Kidney and Monoclonal Gammopathy Research Group
Jan 22, 2015·Kidney International·Frank BridouxUNKNOWN International Kidney and Monoclonal Gammopathy Research Group
Sep 24, 2015·Blood·Rabya H SayedJulian D Gillmore
Apr 21, 2017·International Urology and Nephrology·Mariana CiocchiniCarlos G Musso
Jul 13, 2017·American Journal of Hematology·Angela Dispenzieri
Apr 29, 2018·Journal of the American Society of Nephrology : JASN·Sanjeev SethiVivette D D'Agati
May 30, 2019·British Journal of Haematology·Akhil KheraKarthik Ramasamy
Aug 15, 2019·Blood Advances·Ankur JainKarthik Ramasamy
Dec 12, 2019·Nephrology·Camila PeñaUNKNOWN Grupo de estudio latinoamericano de mieloma múltiple (GELAMM)

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