PMID: 11019710Oct 6, 2000Paper

Monoclonal immunoglobulin G cryoglobulinemia and multiple myeloma in a domestic shorthair cat

Journal of the American Veterinary Medical Association
F H HickfordT Schermerhorn

Abstract

A 13-year-old castrated domestic shorthair cat was examined because of fever, anorexia, and dermatologic lesions. Crusting, erythema, and well-demarcated purple discoloration of the foot pads and the tips of the pinnae, nose, and tail were seen. A white flocculent precipitate was detected in cooled serum. This precipitate dissolved upon rewarming, consistent with a cryoglobulin. Hypercalcemia, high alanine and aspartate aminotransferase activities, thrombocytopenia, and a monoclonal IgG gammopathy were found. Numerous hepatic nodules were detected by means of abdominal ultrasonography. Cytologic evaluation of fine-needle aspirates of the liver and spleen revealed numerous plasma cells, and evaluation of a bone marrow aspirate revealed plasmacytosis. A diagnosis of multiple myeloma and monoclonal IgG cryoglobulinemia was made, and the cat was euthanatized.

References

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Citations

Sep 4, 2008·Journal of the American Veterinary Medical Association·Sherry L AppelDorothee Bienzle
Mar 1, 2004·Veterinary and Comparative Oncology·A RadhakrishnanC A Clifford
Dec 8, 2015·The Journal of Veterinary Medical Science·Masaya IgaseMasaru Okuda
Nov 29, 2012·Journal of Feline Medicine and Surgery·Danny W ScottHollis N Erb
Jan 27, 2009·Diagnostic Cytopathology·Hung ChangYu-Hsin Hung

Related Concepts

Monoclonal Antibodies
Cat Diseases
Felis catus
Cryoglobulinemia
Polyglobin
Liver
Multiple Myeloma
Kaolin-Cephalin Coagulation Time
Fatal Outcome

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