PMID: 9003465Dec 1, 1996Paper

Monocyte activation by an oral immunomodulator (bestatin) in lymphoma patients following autologous bone marrow transplantation

Cancer Immunology, Immunotherapy : CII
K InoJ E Talmadge

Abstract

Bestatin (ubenimex), an inhibitor of aminopeptidase, is an oral immunomodulator that binds to CD13 (aminopeptidase N) on macrophages/monocytes. To examine its immunomodulatory effect after high-dose therapy and autologous bone marrow transplantation (BMT), a dose-finding phase Ib trial was conducted with 30 Hodgkin's disease and non-Hodgkin's lymphoma patients who received no drug (control), 10 and 30 mg (low dose), or 90 and 180 mg (high dose) of bestatin daily for 60 days following autologous BMT. Bestatin administration was initiated when the absolute neutrophil count was greater than 250/mm3 on 2 consecutive days. The serum neopterin levels, an indicator of monocyte/macrophage activation, increased in the high-dose group compared to the control group (not significantly) and the low-dose group (significantly). Similarly, the colony-stimulating activity in the sera was significantly increased in the high-dose group compared to the control and low-dose groups. We also examined the expression of cell-surface markers on monocytes in these patients by fluorescent cytometry analysis. There was no significant difference either in the frequency or absolute number of monocytes (CD14+) among the three groups at any time. However, a si...Continue Reading

Citations

Jan 4, 2001·International Journal of Immunopharmacology·J E TalmadgeS Buyukberber
Jul 17, 2003·Journal of the National Cancer Institute·Xiaoxin ChenChung S Yang
Apr 17, 2003·Journal of the National Cancer Institute·Yukito IchinoseUNKNOWN NK421 Lung Cancer Surgery Group
Mar 13, 2016·International Immunopharmacology·James E Talmadge
Apr 6, 2013·Immunology Letters·Laura J ApplebyFrancisca Mutapi
Oct 11, 2005·Medicinal Research Reviews·Brigitte Bauvois, Daniel Dauzonne
Feb 24, 2012·Pharmacological Reports : PR·Magdalena Lis, Bożena Obmińska-Mrukowicz
Apr 17, 1998·Immunopharmacology and Immunotoxicology·N Y ViskovaV I Dizha
May 16, 2019·EBioMedicine·Simin ZhaoZigang Dong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.