Monocyte and Alveolar Macrophage Skewing Is Associated with the Development of Pulmonary Arterial Hypertension in a Primate Model of HIV Infection

AIDS Research and Human Retroviruses
Finja SchweitzerKaren A Norris

Abstract

We investigated the relationship of monocytes, alveolar, and tissue-resident macrophage populations and the development of pulmonary arterial hypertension (PAH) in a nonhuman primate model of HIV infection. A prospective study of simian immunodeficiency virus-associated pulmonary arterial hypertension (SIV-PAH) was done. Rhesus macaques (n = 21) were infected with SIV. Blood, bronchoalveolar lavage fluid (BALF), and lung tissue were analyzed for monocyte and macrophage phenotypes and inflammatory mediators. Serial right heart catheterizations were performed at three time points throughout the study to assess hemodynamic alterations and the development of PAH. All 21 animals showed similar courses of SIV infection with an increasing proinflammatory plasma environment. At 6 months postinfection (mpi), 11 of 21 animals developed SIV-PAH (mPAP ≤25 mmHg; right ventricular systolic pressure [RVSP] ≤36 mmHg). PAH+ animals had an increased frequency of proinflammatory, nonclassical monocytes (CD14dimCD16+) (p = .06) in the peripheral blood and CD14+CCR7-CD163-CD206+ macrophages (p = .04) in BALF compared with PAH- animals at 6 mpi. Increased frequencies of these monocyte and macrophage phenotypes correlated with elevated RVSP (p = .04;...Continue Reading

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Citations

May 27, 2020·American Journal of Respiratory Cell and Molecular Biology·M Patricia GeorgeBrian B Graham
Sep 16, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charles Preston NeffBrent E Palmer
Apr 2, 2021·Frontiers in Cardiovascular Medicine·Haihua QiuYuan Guo
May 21, 2021·American Journal of Respiratory Cell and Molecular Biology·Balaji KrishnamacharyNavneet K Dhillon

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Methods Mentioned

BETA
bronchoalveolar
lavage
bronchoalveolar lavage
ELISA
Assay
flow cytometry

Software Mentioned

Prism
FlowJo
GraphPad

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