Monocyte and macrophage activation by lipoteichoic Acid is independent of alanine and is potentiated by hemoglobin

The Journal of Immunology : Official Journal of the American Association of Immunologists
D HastyI Ofek

Abstract

Lipoteichoic acids (LTAs) are Gram-positive bacterial cell wall components that elicit mononuclear cell cytokine secretion. Cytokine-stimulating activity is thought to be dependent on retaining a high level of ester-linked D-alanine residues along the polyglycerol phosphate backbone. However, Streptococcus pyogenes LTA essentially devoid of D-alanine caused human and mouse cells to secrete as much IL-6 as LTA with a much higher D-alanine content. Furthermore, hemoglobin (Hb) markedly potentiates the stimulatory effect of various LTAs on mouse macrophages or human blood cells, regardless of their d-alanine content. LTA and Hb appear to form a molecular complex, based on the ability of each to affect the other's migration on native acrylamide gels, their comigration on these gels, and the ability of LTA to alter the absorption spectra of Hb. Because S. pyogenes is known to release LTA and secrete at least two potent hemolytic toxins, LTA-Hb interactions could occur during streptococcal infections and might result in a profound alteration of the local inflammatory response.

References

May 1, 1975·The Journal of Experimental Medicine·I OfekG L Campbell
Apr 1, 1976·The Journal of Experimental Medicine·E H Beachey, I Ofek
Dec 1, 1991·Infection and Immunity·S BhakdiW Fischer
Jan 1, 1990·Methods in Enzymology·C C Winterbourn
Nov 1, 1990·Infection and Immunity·O Leon, C Panos
Jul 10, 1987·Biochimica Et Biophysica Acta·M BatleyA J Wicken
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·D W DunneK A Joiner
Mar 15, 1997·European Journal of Biochemistry·W FischerH Labischinski
Apr 1, 1997·Infection and Immunity·D SuJ Levin
Feb 7, 2001·The Journal of Experimental Medicine·S MorathT Hartung
Jan 18, 2002·Infection and Immunity·Siegfried MorathThomas Hartung
Apr 12, 2002·The Lancet Infectious Diseases·Isaac Ginsburg
Jun 19, 2002·Shock·Huan YangKevin J Tracey
Jun 19, 2002·The Journal of Experimental Medicine·Siegfried MorathThomas Hartung
Feb 25, 2003·The Journal of Infectious Diseases·Oliver GoldmannEva Medina
Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susanne DeiningerThomas Hartung
Dec 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Francis C Neuhaus, James Baddiley
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas J LynchWilhelm J Schwaeble
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philipp HennekeDouglas T Golenbock
Jun 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Corinne GrangetteAnnick Mercenier

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Citations

Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sylvia KnappTom van der Poll
May 5, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rohini Garg, Ayub Qadri
Jul 28, 2020·Journal of Leukocyte Biology·Naveen SharmaAyub Qadri
May 5, 2010·Immunology and Cell Biology·Ricardo F AntunesFernando A Arosa
Sep 30, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Anna GustafssonLennart Ljunggren

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