Monocyte and microglial activation in patients with mood-stabilized bipolar disorder

Journal of Psychiatry & Neuroscience : JPN
Joel JakobssonMikael Landén

Abstract

Bipolar disorder is associated with medical comorbidities that have been linked to systemic inflammatory mechanisms. There is, however, limited evidence supporting a role of neuroinflammation in bipolar disorder. Here we tested whether microglial activation and associated tissue remodelling processes are related to bipolar disorder by analyzing markers in cerebrospinal fluid (CSF) and serum from patients and healthy controls. Serum was sampled from euthymic patients with bipolar disorder and healthy controls, and CSF was sampled from a large subset of these individuals. The levels of monocyte chemoattractant protein-1 (MCP-1), YKL-40, soluble cluster of differentiation 14 (sCD14), tissue inhibitor of metalloproteinases-1 (TIMP-1) and tissue inhibitor of metalloproteinases-2 (TIMP-2), were measured, and we adjusted comparisons between patients and controls for confounding factors. We obtained serum samples from 221 patients and 112 controls and CSF samples from 125 patients and 87 controls. We found increased CSF levels of MCP-1 and YKL-40 and increased serum levels of sCD14 and YKL-40 in patients compared with controls; these differences remained after controlling for confounding factors, such as age, sex, smoking, blood-CSF ba...Continue Reading

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Citations

Feb 10, 2016·Biological Chemistry·Yahaira M NaaldijkHenning Ulrich
Mar 17, 2016·Cellular and Molecular Life Sciences : CMLS·Hans O Kalkman, Dominik Feuerbach
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Jun 12, 2021·Journal of Biomedical Science·Gregory H JonesRodrigo Machado-Vieira

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