Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019.

The Journal of Infectious Diseases
A.-S. BedinEdouard TUAILLON

Abstract

We assessed the expression of CD169, a type I interferon-inducible receptor, on monocytes (monocyte CD169 [mCD169]) in 53 adult patients admitted to the hospital during the coronavirus disease 2019 (COVID-19) outbreak for a suspicion of severe acute respiratory syndrome coronavirus 2 infection. Monocyte CD169 was strongly overexpressed in 30 of 32 (93.7%) confirmed COVID-19 cases, compared with 3 of 21 (14.3%) patients in whom the diagnosis of COVID-19 was finally ruled out. Monocyte CD169 was associated with the plasma interferon-alpha level and thrombocytopenia. Monocyte CD169 testing may be helpful for the rapid triage of suspected COVID-19 patients during an outbreak.

References

Feb 18, 2020·Future Microbiology·Pénélope BourgoinThibaut Markarian

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Citations

Nov 25, 2020·JCI Insight·Michael S AbersLuigi D Notarangelo
Apr 11, 2021·Journal for Immunotherapy of Cancer·Paolo Antonio AsciertoHaiming Wei
Jun 11, 2021·Frontiers in Immunology·Vanessa ChilundaJoan W Berman
Aug 17, 2021·Frontiers in Immunology·Alsya J AffandiJoke M M den Haan
Sep 21, 2021·Glycoconjugate Journal·Irena Trbojević-AkmačićGordan Lauc
Oct 7, 2021·PLoS Pathogens·Elena WinheimAnne B Krug
Oct 23, 2021·European Journal of Immunology·Hector Rincon-ArevaloEva V Schrezenmeier

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