Monocyte Chemoattractant Protein-1 as a Predictor of Coronary Atherosclerosis in Patients Receiving Coronary Angiography

Critical Pathways in Cardiology
Simon A MahlerChadwick D Miller

Abstract

Animal studies suggest that monocyte chemoattractant protein-1 (MCP-1) is a promising biomarker for coronary artery atherosclerosis (CAA), but human studies have been inconclusive. To determine potential relationships between plasma MCP-1 and CAA in patients with acute chest pain. A secondary analysis of 150 patients enrolled in emergency department chest pain risk stratification clinical investigations was conducted. Participants with stored blood and known coronary phenotypes (determined by coronary angiography) were selected using stratified randomization such that 50 patients were included into 3 groups: (1) no angiographic evidence of CAA, (2) nonobstructive CAA, and (3) obstructive CAA (stenosis ≥ 70%). Plasma MCP-1 levels were determined by enzyme-linked immunosorbent assay. The association between MCP-1 and obstructive CAA or any CAA was modeled using logistic regression. Variables in the unreduced model included age, sex, race, prior diagnosis of CAA or acute coronary syndrome, hyperlipidemia, hypertension, diabetes, smoking, and cardiac troponin I measurement. Among the 150 participants, 65.3% (98/150) had invasive coronary angiography and 34.7% (52/150) had coronary computed tomographic angiography. Myocardial infarc...Continue Reading

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Citations

Jul 22, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Chang-Meng WuYan-Wei Hu
Dec 23, 2019·Cytokine·Volatiana RakotoariveloSheela Ramanathan
Mar 23, 2021·Journal of Immunoassay & Immunochemistry·Abdulmecit AfşinAykut Dündar
Dec 23, 2021·Emergency Medicine Journal : EMJ·Nicklaus P AshburnSimon A Mahler

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