Monocyte chemoattractant protein-1 immunoreactivity in sensory ganglia and hindpaw after adjuvant injection

Neuroreport
Sang-Min JeonHee-Jung Cho

Abstract

Monocyte chemoattractant protein-1 (MCP-1)/CCL2 is a member of the CC chemokine family that exhibits potent chemotactic activity for monocytes/macrophages. In the current study, the proportion of monocyte chemoattractant protein-1-immunoreactive (IR) neurons in the dorsal root ganglion (DRG) of rats was shown to increase markedly following adjuvant injection into the hindpaw. MCP-1-IR axon terminals were not found in the spinal cord or hindpaw of control or adjuvant-treated rats. Instead, the inflamed hindpaw dermis was infiltrated by numerous MCP-1-IR inflammatory cells. Following adjuvant injection, the majority of MCP-1-IR neurons in the DRG colocalized with IB4 binding. Our findings suggest that peripheral tissue inflammation induces increased MCP-1 expression in DRG neurons and this may be dependent upon glial cell line-derived neurotrophic factor.

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Citations

Oct 15, 2013·Neuroscience Letters·John M Dawes, Stephen B McMahon
Sep 12, 2008·Current Opinion in Anaesthesiology·Fletcher A White, Natalie M Wilson
Oct 15, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Peter T OharaLuc Jasmin
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Oct 3, 2017·Rheumatology·Ramin RaoofNiels Eijkelkamp
Mar 13, 2021·Open Access Rheumatology : Research and Reviews·Anthony Sebba

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