Monocyte chemoattractant protein-2 (CC chemokine ligand 8) inhibits replication of human immunodeficiency virus type 1 via CC chemokine receptor 5

The Journal of Infectious Diseases
Otto O YangAndrew D Luster

Abstract

CC chemokine receptor 5 (CCR5) is a coreceptor for cellular entry of monocyte-tropic (R5) strains of human immunodeficiency virus (HIV) type 1, which has been implicated as the predominant phenotype of HIV in early infection. The CCR5 agonists macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES (regulated on activation, normally T cell-expressed and -secreted) have been shown to block replication of R5 virus in vitro and have gained attention as potential antiviral factors. However, a few reports have suggested that other chemokines may also block R5 HIV-1, including monocyte chemoattractant protein (MCP)-2 (CC chemokine ligand 8). We demonstrate that MCP-2 specifically inhibits replication of R5 HIV-1 and that this activity is additive to that of RANTES. Furthermore, MCP-2 induces a robust, pertussis toxin-sensitive calcium flux in primary lymphocytes, and cross-desensitization studies indicate that MCP-2 acts via CCR5. These data confirm that MCP-2 is a ligand for CCR5 on CD4(+) lymphocytes and can specifically block R5 HIV-1.

Citations

Feb 26, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Slava RomFrancesca Peruzzi
Jul 5, 2005·Journal of Virology·Mayra GarcíaWilliam J Moss
Jun 11, 2015·International Journal of Molecular Sciences·Julio Valdivia-SilvaEduardo A Garcia-Zepeda
Nov 24, 2004·FEMS Microbiology Letters·Eric de Silva, Michael P H Stumpf
Aug 13, 2013·PLoS Neglected Tropical Diseases·Jordana Grazziela Alves Coelho-dos-ReisOlindo Assis Martins-Filho
Mar 30, 2017·PloS One·Michelle ZanoniRicardo Sobhie Diaz
Mar 21, 2020·Journal of Neurovirology·Naomi SwantaKathleen Borgmann

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