Abstract
CC chemokine receptor 5 (CCR5) is a coreceptor for cellular entry of monocyte-tropic (R5) strains of human immunodeficiency virus (HIV) type 1, which has been implicated as the predominant phenotype of HIV in early infection. The CCR5 agonists macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES (regulated on activation, normally T cell-expressed and -secreted) have been shown to block replication of R5 virus in vitro and have gained attention as potential antiviral factors. However, a few reports have suggested that other chemokines may also block R5 HIV-1, including monocyte chemoattractant protein (MCP)-2 (CC chemokine ligand 8). We demonstrate that MCP-2 specifically inhibits replication of R5 HIV-1 and that this activity is additive to that of RANTES. Furthermore, MCP-2 induces a robust, pertussis toxin-sensitive calcium flux in primary lymphocytes, and cross-desensitization studies indicate that MCP-2 acts via CCR5. These data confirm that MCP-2 is a ligand for CCR5 on CD4(+) lymphocytes and can specifically block R5 HIV-1.
Citations
Dec 13, 2006·Journal of Neurovirology·Jianbin Wang, Dana Gabuzda
Feb 26, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Slava RomFrancesca Peruzzi
Jul 5, 2005·Journal of Virology·Mayra GarcíaWilliam J Moss
Oct 28, 2006·Blood·J Mohamad FakruddinTomozumi Imamichi
Nov 10, 2013·PloS One·Edward SeungAndrew M Tager
Dec 3, 2009·Endocrine Journal·Kishiko NakajimaKanji Sato
Jun 11, 2015·International Journal of Molecular Sciences·Julio Valdivia-SilvaEduardo A Garcia-Zepeda
Apr 22, 2006·Microbial Pathogenesis·Matthew RarickMonty Montano
Aug 24, 2005·Immunology Letters·Fabrizio PocciaMiroslav Malkovsky
Apr 30, 2015·AIDS Research and Human Retroviruses·Zahra ToossiChristina S Hirsch
Nov 10, 2011·FEMS Immunology and Medical Microbiology·Rajnish S Dave
Nov 24, 2004·FEMS Microbiology Letters·Eric de Silva, Michael P H Stumpf
Feb 15, 2013·PLoS Neglected Tropical Diseases·Fabio E LealEsper G Kallas
Aug 13, 2013·PLoS Neglected Tropical Diseases·Jordana Grazziela Alves Coelho-dos-ReisOlindo Assis Martins-Filho
Mar 30, 2017·PloS One·Michelle ZanoniRicardo Sobhie Diaz
Jan 25, 2020·PloS One·Michael BobardtPhilippe Gallay
Mar 21, 2020·Journal of Neurovirology·Naomi SwantaKathleen Borgmann
Feb 2, 2018·PloS One·Henk-Jan van den HamUNKNOWN DC-TRN trial investigators
Jun 26, 2020·Frontiers in Molecular Neuroscience·Weihao FanLili Cui