Monocyte chemotactic protein-3: possible involvement in apical periodontitis chemotaxis

International Endodontic Journal
Andrea DezeregaMarcela Hernández

Abstract

To study the expression of monocyte chemotactic protein-3 (MCP-3, also known as chemokine CCL-7) in tissue from apical lesions (AL) and to associate MCP-3 expression with symptomatic or asymptomatic apical periodontitis. To determine the expression of MCP-3 in AL, biopsies obtained during tooth extraction procedures were fixed, subjected to routine processing and diagnosed as apical granuloma (AG) (n = 7) or radicular cyst (RC) (n = 5). As controls, apical periodontal ligament (PDL) specimens from healthy premolars extracted for orthodontics reasons were included (n = 7). All specimens were immunostained for MCP-3 and examined under a light microscope. In addition, homogenates from AL (n = 14) and healthy PDL samples (n = 7) were studied through immunowestern blot. Finally, periapical exudates samples were collected from root canals of teeth having diagnosis of symptomatic (n = 14) and asymptomatic apical periodontitis (n = 14) during routine endodontic treatments and analysed by immunowestern blot and densitometry. MCP-3 was detected in AG and RC and localized mainly to inflammatory leucocytes, whereas no expression was observed in healthy PDLs. MCP-3 was also detected in periapical exudate, and its levels were significantly h...Continue Reading

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Citations

Nov 26, 2015·Journal of Endodontics·Lisiane BernardiPantelis Varvaki Rados
Jul 9, 2013·International Endodontic Journal·L WangB Peng
Jan 17, 2021·Archives of Oral Biology·Keng-Fu LanXiaojun Ding
Aug 31, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Qiburi QiburiHuricha Baigude

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