Monocyte derived dendritic cells from HIV-1 infected individuals partially reconstitute CD4 T-cell responses

AIDS
Philippa J NewtonBenjamin M Chain

Abstract

The study tests the hypothesis that monocyte derived dendritic cells from HIV-1 infected individuals are normal and can restore impaired CD4 T-cell antigen specific responses. Monocyte derived dendritic cells were isolated from individuals at three different stages of HIV-1 infection with a wide spectrum of viral load and CD4 T-cell counts, and from healthy volunteers. The cell surface phenotype and allogeneic stimulatory potential of these dendritic cells was documented. CD4 T-cell responses to HIV p24, tetanus toxoid and purified protein derivative were measured using either unfractionated peripheral blood mononuclear cells, or purified dendritic cell/T-cell cultures. Dendritic cells from all three HIV-1 infected groups did not differ from each other or from healthy volunteers in terms of cell surface phenotype or allogeneic stimulatory potential using T cells from healthy volunteers. Dendritic cells from immunosuppressed antiretroviral naive individuals enhanced the autologous recall proliferative responses both to HIV-1 p24, and third party antigens tetanus toxoid and purified protein derivative, both in terms of the proportion of responding individuals, and median proliferation. Antigen presentation by dendritic cells part...Continue Reading

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Citations

Nov 25, 2006·The Lancet Infectious Diseases·Mahdad NoursadeghiRobert F Miller
Dec 20, 2008·Journal of Internal Medicine·C R Rinaldo
Jun 20, 2014·Journal of Virology·Kellie N SmithCharles R Rinaldo
Jul 20, 2007·Clinical and Vaccine Immunology : CVI·Zheng FanCharles R Rinaldo
Aug 21, 2009·Clinical and Vaccine Immunology : CVI·Xiao-Li HuangCharles R Rinaldo

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