Monocyte-derived dendritic cells over-express CD86 in patients with systemic lupus erythematosus

Rheumatology
Patrice DeckerHans-Georg Rammensee

Abstract

Dendritic cells (DCs) play a key role in regulating immune responses, especially in priming naïve T-cells. Recently, DCs have been suggested to be involved in systemic lupus erythematosus (SLE) development by activating autoreactive T-helper lymphocytes. As a consequence, we compared the activation state of human monocyte-derived DCs (MDDCs) obtained from lupus patients and normal individuals. The MDDCs were generated in vitro from blood from healthy donors and lupus patients. Immature and mature MDDCs were analysed by flow cytometry for several cell surface molecules. In parallel, cytokine secretion was determined by ELISA before and after MDDC activation. In each experiment, lupus DCs were compared with normal DCs. Here, we show for the first time that lupus MDDCs spontaneously over-express CD86 in the absence of any DC activation signal as compared with normal MDDCs (P = 0.025). Moreover, activation-induced IL-6 secretion was increased in lupus DCs with high CD86 over-expression as compared with normal DCs (P = 0.010). Interestingly, the percentage of MDDCs in lupus preparations is negatively correlated with disease activity scores (SLEDAI; P = 0.031). Lupus MDDCs are pre-activated suggesting that they might be more efficien...Continue Reading

References

Jul 5, 1979·The New England Journal of Medicine·J J HooksA L Notkins
Dec 1, 1988·Immunology Letters·C SchüttH Friemel
Jan 1, 1993·Journal of Clinical Immunology·M al-JanadiS Raziuddin
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Aug 18, 2001·Cell·A Lanzavecchia, F Sallusto
Sep 13, 2002·Immunology and Cell Biology·Lois L Cavanagh, Ulrich H Von Andrian
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patrice DeckerHans-Georg Rammensee

❮ Previous
Next ❯

Citations

Aug 19, 2007·Immunologic Research·Seetha Monrad, Mariana J Kaplan
Aug 3, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Yi LiWestley H Reeves
Aug 5, 2010·Apoptosis : an International Journal on Programmed Cell Death·Dror Mevorach
Nov 14, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Luciano CastielloDavid F Stroncek
Dec 2, 2008·Arthritis Research & Therapy·David A Horwitz
Nov 11, 2014·Nature Medicine·Menna R ClatworthyRonald N Germain
Mar 28, 2013·Clinical & Developmental Immunology·Dinglei SuLingyun Sun
Oct 19, 2007·Seminars in Immunopathology·Menna R Clatworthy, Kenneth G C Smith
Sep 18, 2014·International Journal of Molecular Sciences·Juan P Mackern-ObertiAlexis M Kalergis
Mar 17, 2016·Journal of Immunology Research·Meng WuJunwei Chen
Oct 9, 2009·Autoimmunity·Dennis Lindau, Patrice Decker
Nov 29, 2015·European Journal of Immunology·Patrick BlancoNathalie Schmitt
Feb 23, 2013·Molecular Immunology·Maria Alejandra GleisnerMaria Rosa Bono
Jun 5, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Melissa A CunninghamGary S Gilkeson
Apr 17, 2012·Autoimmunity Reviews·Vera Sau-Fong ChanChak-Sing Lau
Feb 14, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Pierre Duffau, Patrick Blanco
Jan 14, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·José C CrispínJorge Alcocer-Varela
May 1, 2009·Human Immunology·Sergio RutellaGianfranco Ferraccioli
Jan 17, 2009·Seminars in Arthritis and Rheumatism·Christina G KatsiariPetros P Sfikakis
Dec 9, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Colin EdgertonGeorge C Tsokos
Jul 10, 2010·Journal of Biomedicine & Biotechnology·E Kassi, P Moutsatsou
Jul 24, 2007·Autoimmunity Reviews·Jose C Crispin, Jorge Alcocer-Varela
Nov 12, 2013·Scientific Reports·Tania KonryMartin Yarmush
Jul 17, 2009·Clinical and Experimental Immunology·A NalbandianG C Tsokos
Aug 22, 2006·Scandinavian Journal of Immunology·P VogelsangS Appel
Oct 30, 2008·European Journal of Immunology·Yackov BerkunDror Mevorach
Sep 22, 2011·Clinical and Experimental Dermatology·F L ShawC E M Griffiths
Apr 29, 2016·Mediators of Inflammation·Jared KlarquistEdith M Janssen
Jun 19, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Carolina LlanosAlexis M Kalergis
Jul 23, 2011·Immunology Letters·Roland JonssonSilke Appel
Dec 3, 2014·Autoimmunity Reviews·Juan Pablo Mackern-ObertiAlexis M Kalergis
May 1, 2007·Arthritis and Rheumatism·Peter E WesterweelMarianne C Verhaar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.