Monocyte human leukocyte antigen - Antigen D related, neutrophil oxidative burst and cytokine analysis in patients of decompensated cirrhosis with and without acute-on chronic liver failure

PloS One
Sandeep SatsangiYogesh Chawla

Abstract

Due to a dysregulated immune response, patients with acute-on-chronic liver failure (ACLF) have increased risk of infection and multi organ failure in comparison to compensated cirrhosis. The comparative data on the presence of 'immune paresis' in patients with ACLF and decompensated cirrhosis without ACLF is not available. Aim of the present study was to compare the immunological parameters in patients with decompensated cirrhosis with and without ACLF. In a prospective study, 76 patients with decompensated cirrhosis with (n = 38) and without (n = 38) ACLF and 10 healthy controls (HC) were evaluated for monocytic human leukocyte antigen-antigen D Related (HLA-DR) expression, mean density of HLA-DR expressed on the surface of these cells, neutrophil oxidative burst (NOB) capacity and serum levels of cytokines (IL-1, IL-6, IL-8, IL10, IL-12, and TNF-α). Patients of decompensated cirrhosis with and without ACLF demonstrated significantly lower mean percentage of monocytes expressing HLA-DR and quantitative increase in the NOB after stimulation with PMA when compared to HC. However there was no difference in mean percentage of monocytes with HLA-DR expression (43.61±26.56% vs. 43.10±20.98%) (p = 0.91), mean density of HLA-DR expre...Continue Reading

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Citations

Jan 25, 2020·The Veterinary Record·Craig R BrehenyRichard J Mellanby
Mar 16, 2019·Frontiers in Immunology·Katharine Margaret IrvineDavid Arthur Hume
Apr 3, 2020·Journal of Hepatology·Christine BernsmeierAxel Périanin

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Methods Mentioned

BETA
biopsy
PMA
FACS

Software Mentioned

GraphPad
Cell Quest Pro
FCAP
GraphPad Prism
SPSS

Related Concepts

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