Monocyte human leukocyte antigen-DR but not β-D-glucan may help early diagnosing invasive Candida infection in critically ill patients.

Annals of Intensive Care
Boris JungSamir Jaber

Abstract

Precision medicine risk stratification is desperately needed to both avoid systemic antifungals treatment delay and over prescription in the critically ill with risk factors. The aim of the present study was to explore the combination of host immunoparalysis biomarker (monocyte human leukocyte antigen-DR expression (mHLA-DR)) and Candida sp wall biomarker β-D-glucan in risk stratifying patients for secondary invasive Candida infection (IC). Prospective observational study. Two intensive care units (ICU). All consecutive non-immunocompromised septic shock patients. Serial blood samples (n = 286) were collected at day 0, 2 and 7 and mHLA-DR and β-D-glucan were then retrospectively assayed after discharge. Secondary invasive Candida sp infection occurrence was then followed at clinicians' discretion. Fifty patients were included, 42 (84%) had a Candida score equal or greater than 3 and 10 patients developed a secondary invasive Candida sp infection. ICU admission mHLA-DR expression and β-D-glucan (BDG) failed to predict secondary invasive Candida sp infection. Time-dependent cause-specific hazard ratio of IC was 6.56 [1.24-34.61] for mHLA-DR < 5000 Ab/c and 5.25 [0.47-58.9] for BDG > 350 pg/mL. Predictive negative value of mHLA-DR...Continue Reading

References

Aug 5, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Luis Ostrosky-ZeichnerJohn H Rex
Jun 3, 2006·Intensive Care Medicine·Guillaume MonneretPhilippe Vanhems
Mar 3, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L Ostrosky-ZeichnerJ H Rex
Nov 21, 2007·Molecular Medicine·Guillaume MonneretAlain Lepape
May 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ben De PauwUNKNOWN National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
Jun 6, 2009·American Journal of Epidemiology·Bryan LauStephen J Gange
Oct 30, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sophia KooFrancisco M Marty
Dec 3, 2009·JAMA : the Journal of the American Medical Association·Jean-Louis VincentUNKNOWN EPIC II Group of Investigators
Aug 5, 2010·Critical Care Medicine·Jeannina A Smith, Carol A Kauffman
Sep 8, 2010·Medical Mycology·Luis Ostrosky-ZeichnerJohn R Perfect
Nov 26, 2010·Critical Care : the Official Journal of the Critical Care Forum·Aurélie CheronGuillaume Monneret
Mar 4, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Drosos E KarageorgopoulosMatthew E Falagas
Mar 12, 2011·Nature Reviews. Immunology·Luigina Romani
Sep 22, 2011·Critical Care : the Official Journal of the Critical Care Forum·Jian-Feng WuXiang-Dong Guan
Oct 25, 2011·Critical Care : the Official Journal of the Critical Care Forum·Brunella PosteraroMassimo Antonelli
Dec 27, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Frédéric LamothUNKNOWN Third European Conference on Infections in Leukemia (ECIL-3)
Feb 3, 2012·Critical Care Medicine·Elie AzoulayJean-François Timsit
Mar 14, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David R AndesUNKNOWN Mycoses Study Group
Jun 5, 2012·The New England Journal of Medicine·Julie R BrahmerJon M Wigginton
Jun 26, 2012·Anesthesiology·Karim AsehnouneEdward Abraham
Jan 4, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·O A CornelyUNKNOWN ESCMID Fungal Infection Study Group
Jan 15, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cornelius J Clancy, M Hong Nguyen
Feb 23, 2013·The Lancet Infectious Diseases·Richard S HotchkissDidier Payen
Jun 21, 2013·American Journal of Respiratory and Critical Care Medicine·Frederic TissotUNKNOWN Fungal Infection Network of Switzerland (FUNGINOS)
Jul 16, 2013·Journal of Clinical Microbiology·Elitza S Theel, Christopher D Doern
Feb 20, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Luis Ostrosky-ZeichnerPeter G Pappas
Feb 22, 2014·Critical Care Medicine·Mireia Puig-AsensioUNKNOWN Spanish Network for Research in Infectious Diseases
Apr 2, 2014·Annales Françaises D'anesthèsie Et De Rèanimation·P MassanetP Corne
Aug 7, 2014·Intensive Care Medicine·Olivier LortholaryUNKNOWN French Mycosis Study Group
Oct 9, 2015·The New England Journal of Medicine·Bart Jan Kullberg, Maiken C Arendrup
Nov 3, 2015·Current Opinion in Infectious Diseases·Ryan K ShieldsCornelius J Clancy
Jan 9, 2016·Annals of Intensive Care·Olivier LeroyUNKNOWN AmarCAND2 study group
Apr 30, 2016·The Journal of Antimicrobial Chemotherapy·Brunella PosteraroMassimo Antonelli
Jun 12, 2016·The Journal of Antimicrobial Chemotherapy·Marcio NucciArnaldo L Colombo
Jul 16, 2016·Open Forum Infectious Diseases·Cécile AngebaultMarie-Elisabeth Bougnoux
Oct 27, 2016·Immunological Reviews·Matthew J Delano, Peter A Ward
Nov 24, 2016·The Journal of Antimicrobial Chemotherapy·Matteo BassettiJean-Francois Timsit
Mar 4, 2017·Intensive Care Medicine·Matteo BassettiOliver A Cornely
Mar 23, 2017·Intensive Care Medicine·Olivier LortholaryUNKNOWN French Mycoses Study Group
Nov 24, 2017·Intensive Care Medicine·Jigar V DesaiMichail S Lionakis

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