Monocyte-macrophage system and polymorphonuclear leukocytes in workers exposed to low levels of metallic mercury

The Science of the Total Environment
L VimercatiL Soleo

Abstract

Our previous research (Soleo L, Vacca A, Vimercati L et al. Occup Environ Med 1997;54:437-442) showed a reduction in tumor necrosis factor-alpha (TNF-alpha) serum levels in workers with prolonged exposure to low doses of inorganic mercury, suggesting an in vivo functional defect of the monocyte-macrophage system. On this basis, here we wondered whether workers exposed to lower doses of metallic mercury displayed possible changes in the monocyte-macrophage system. In this particular cohort of workers, we also sought for the effects of the exposure on the polymorphonuclear leukocytes (PMNL) chemotaxis. The monocyte-macrophage system and the natural killer (NK) cells were examined in 19 exposed workers and in 25 unexposed workers, as the control group (controls). Specifically, the circulating monocyte-macrophage cells and their CD13, CD15 and CD33 subsets, serum cytokines (IL-8, GM-CSF and TNF-alpha) and the NK cells were analyzed. In seven exposed and seven controls randomly chosen workers the PMNL chemotaxis was also assessed. The selected indicator of mercury exposure were the levels of mercury in the urine (U-Hg), that was significantly higher in exposed workers than the controls (9.7 +/- 5.5 microg/l and 2.4 +/- 1.2 microg/l,...Continue Reading

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Citations

Sep 1, 2005·Environmental Toxicology and Pharmacology·Farhana ZahirRizwan H Khan
Apr 25, 2007·Journal of Toxicology and Environmental Health. Part a·Rudolfs K ZalupsLucy Joshee
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Apr 27, 2011·Environmental Health : a Global Access Science Source·Ta-Yuan ChangBo-Ying Bao
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Jan 1, 2014·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Guoyan LiuChunyan Chai
May 13, 2018·Environmental Science and Pollution Research International·Rajashree Patnaik, Rabindra N Padhy
Sep 2, 2021·Brazilian Journal of Biology = Revista Brasleira De Biologia·M U IjazS Mahboob

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