PMID: 9002096Jan 1, 1997Paper

Monocyte phagolysosomal fusion in children born to human immunodeficiency virus-infected mothers

The Pediatric Infectious Disease Journal
M G PittisL Sen

Abstract

Previously we demonstrated that monocyte phagolysosomal fusion is impaired in chronic HIV infection in adult patients. We studied the phagolysosomal fusion of peripheral blood monocytes from 45 children vertically infected with HIV, 38 noninfected infants born to HIV-positive mothers and 14 children born to HIV-seronegative women, by a cytomorphologic method in which acridine orange is used as a fusion marker. The mean percentages of phagolysosomal fusion +/-SD were 42 +/- 16.1 for HIV-positive children, 55.3 +/- 15.5 for HIV-negative infants born to HIV-infected mothers and 58.2 +/- 12.7 for normal controls. Monocyte phagolysosomal fusion of HIV-infected children was significantly decreased in comparison to noninfected and normal infants (P < 0.001), while there was no difference between the two latter groups. Phagolysosomal fusion impairment in HIV-infected infants inversely correlated with age (r = -0.4527; P < 0.002) and directly correlated with CD4+ T cell counts (r = 0.393; P = 0.03). Moreover, phagolysosomal fusion strongly correlated with clinical manifestations; this function was significantly impaired in moderately and severely symptomatic HIV-infected children with respect to those who remained asymptomatic or mildly...Continue Reading

References

May 1, 1991·The Journal of Pediatrics·E RoilidesG M Shearer
May 1, 1986·The Journal of Clinical Investigation·D D HoM S Hirsch
Jul 11, 1986·Science·S GartnerM Popovic
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Aug 1, 1994·The Journal of Infectious Diseases·C M WilfertL Epstein
Nov 1, 1993·Scandinavian Journal of Immunology·M G PittisM E Estevez

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