Monocyte Recruitment after High-Intensity and High-Volume Resistance Exercise

Medicine and Science in Sports and Exercise
Adam J WellsJeffrey R Stout

Abstract

The innate immune response is generally considered to have an important role in tissue remodeling after resistance exercise. The purpose of this study was to compare changes in markers of monocyte recruitment after an acute bout of high-intensity (HVY) versus high-volume (VOL) lower-body resistance exercise. Ten resistance-trained men (24.7 ± 3.4 yr, 90.1 ± 11.3 kg, 176.0 ± 4.9 cm) performed each protocol in a randomized, counterbalanced order. Blood samples were collected at baseline, immediately (IP), 30 min (30P), 1 h (1H), 2 h (2H), and 5 h (5H) postexercise. Plasma concentrations of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-α), myoglobin, and cortisol were measured via assay. Tumor necrosis factor receptor 1 (TNFr1), macrophage-1 antigen (cluster of differentiation 11b [CD11b]), and C-C chemokine receptor 2 (CCR2) expression levels were measured using flow cytometry. TNFr1 and CD11b were assessed on CD14CD16 monocytes, whereas CCR2 was assessed on CD14 monocytes. Plasma myoglobin concentrations were significantly greater after HVY compared with VOL (P < 0.001). Changes in plasma TNF-α, MCP-1, and expression levels of CCR2 and CD11b were similar between HVY and VOL. When collapsed across g...Continue Reading

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Citations

Mar 21, 2017·Medicine and Science in Sports and Exercise·Julianne C BarryJonathan P Little
Jun 30, 2018·Medicine and Science in Sports and Exercise·Adam R JajtnerJay R Hoffman
Oct 21, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Johanna K IhalainenAntti A Mero
Nov 30, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Igor Martins da SilvaAlessandra Peres
Apr 28, 2017·European Journal of Applied Physiology·Sandro BartolomeiJay R Hoffman
Sep 19, 2020·Journal of Strength and Conditioning Research·Adam J WellsJay R Hoffman
Oct 27, 2020·Journal of Strength and Conditioning Research·Adam J WellsJay R Hoffman

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