Monocyte recruitment in cryoglobulinemic membranoproliferative glomerulonephritis: a pathogenetic role for monocyte chemotactic peptide-1

Kidney International
L GesualdoF P Schena

Abstract

Monocyte chemotactic peptide-1 (MCP-1) belongs to a large family of cytokines known as chemokines. It is a potent mediator of inflammatory response and is thought to play a major role in recruiting monocytes into the site of inflammation. Mixed cryoglobulinemia is a systemic vasculitis characterized in 10 to 30% of the cases by renal involvement. Monocyte infiltration into the glomerulus, and in the periglomerular and perivascular areas is a common histopathological feature of this form of glomerulonephritis. We sought to determine, by in situ hybridization and immunohistochemistry, the renal gene and protein expression of MCP-1 in cryoglobulinemic glomerulonephritis compared to normal kidney, and to correlate it with macrophage infiltration. Kidney biopsy specimens were obtained from 9 patients with cryoglobulinemic glomerulonephritis and 9 control kidneys. The distribution and intensity of MCP-1 gene and protein expression, and the macrophage infiltration (CD68 positive cells) were evaluated and quantitated by a computerized image analysis system. In normal kidneys, MCP-1 was weakly expressed, both at the gene as well as at the protein level. In diseased kidneys, a statistically significant (P < 0.001) up-regulation of MCP-1 ...Continue Reading

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Citations

Dec 19, 2001·The Journal of Pathology·Paul CockwellCaroline O S Savage
Jan 22, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rebecca Wing-Yan Chan, Cheuk-Chun Szeto
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Dec 23, 2014·PloS One·Daniella Bezerra DuarteElizabeth De Francesco Daher
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Jan 5, 2000·Journal of the American Society of Nephrology : JASN·Stephan SegererDetlef Schlöndorff
Nov 30, 1999·Journal of the American Society of Nephrology : JASN·B BanasD Schlöndorff
Sep 12, 1998·Kidney International·P CockwellC O Savage
Mar 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G GrandalianoF P Schena
Aug 20, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Min Jeong Kim, Frederick W K Tam

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