Monocyte recruitment in venous thrombus resolution

Journal of Vascular Surgery
Tahir AliAlberto Smith

Abstract

To investigate the importance of monocyte recruitment in thrombus resolution and the role of cysteine-cysteine (CC) chemokines and the CC chemokine receptor, CCR2, in this process. Peritoneal macrophages, monocyte chemotactic protein 1 (MCP1), or carrier solutions were injected into thrombi induced in the vena cava of rats. Caval thrombi were also formed in CCR2-/- and MCP1-/- mice and in wild-type mice transfected with an adenoviral construct expressing a broad-spectrum CC receptor antagonist. Direct administration of peritoneal macrophages decreased thrombus size by more than fivefold and increased recanalization by more than fourfold compared with controls (P < .001). A 100-ng MCP1dose reduced thrombus size by more than sixfold (P < .01) and increased recanalization by more than sevenfold (P < .01), without affecting macrophage recruitment. Deletion of CCR2 or blockade of all CC chemokines inhibited both monocyte recruitment (P < .05) and thrombus resolution (P < .01), but knocking out MCP-1 had no effect. Increasing macrophage numbers in the thrombus enhances its resolution. MCP1 treatment enhances resolution by stimulating recanalization, independent of an effect on monocyte recruitment. CCR2 deficiency has the same effect...Continue Reading

References

Oct 1, 1989·The American Review of Respiratory Disease·D R Knighton, V D Fiegel
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B J RollinsC D Stiles
Aug 1, 1982·Archives of Surgery·K TanakaL L Smith
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·T C HeB Vogelstein
Jun 24, 1999·Cytokine & Growth Factor Reviews·E Van CoillieG Opdenakker
Nov 5, 1999·Journal of Vascular Surgery·T W WakefieldR M Strieter
Jun 3, 2000·Annual Review of Immunology·D Rossi, A Zlotnik
Oct 12, 2000·Journal of the American College of Cardiology·J SchweizerA Graf
Jun 26, 2001·The Journal of Surgical Research·P K HenkeR M Strieter
Oct 3, 2003·Trends in Cardiovascular Medicine·Nicanor I Moldovan, Takayuki Asahara
Sep 1, 2004·Journal of Vascular Surgery·Manu R VarmaPeter K Henke

❮ Previous
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Citations

Jan 27, 2012·Journal of Thrombosis and Thrombolysis·April L RodriguezJose A Diaz
Jun 17, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·David A FerenbachDavid C Kluth
Feb 18, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Prakash SahaAlberto Smith
Sep 22, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Crystal M RipplingerFarouc A Jaffer
Jun 8, 2011·The Journal of Clinical Investigation·Mizuho NosakaToshikazu Kondo
Dec 3, 2015·Expert Review of Hematology·Johanna AltmannIrene M Lang
Aug 23, 2012·Thrombosis Research·Colin E EvansAlberto Smith
Mar 9, 2012·Thrombosis Research·Brian C Cooley
Jun 13, 2009·Thrombosis Research·Peter K Henke, Thomas Wakefield
Jun 6, 2014·Thrombosis and Haemostasis·M CushmanM H Criqui
Oct 16, 2015·Blood Reviews·Arina J ten Cate-HoekThomas W Wakefield
Apr 30, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Se-Il GoGyeong-Won Lee
Jan 1, 2015·Nature Reviews. Disease Primers·Alisa S WolbergNigel Mackman
Mar 25, 2008·Journal of Vascular Surgery·Yi-kuan ChenJian-ping Gong
Aug 8, 2007·Journal of Vascular Surgery·Lornie J Phillips, Rajabrata Sarkar
Oct 3, 2008·Journal of Vascular Surgery·Fatiha BouzeghraneJean Raymond
Jan 31, 2012·Thrombosis Research·Brian C CooleyGregory Schmeling
Mar 20, 2012·Thrombosis Research·Colin E EvansAlberto Smith
Sep 18, 2016·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Katherine A GallagherPeter K Henke
Sep 23, 2016·Internal and Emergency Medicine·Chiara MozziniLuciano Cominacini
Mar 17, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Qingyou MengChuanyong Li
Jan 18, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Colin E EvansAlberto Smith
Oct 12, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Colin Edward EvansAlberto Smith
Feb 2, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Diana BondermanIrene M Lang
Oct 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Mizuho NosakaToshikazu Kondo
Aug 2, 2017·Journal of Thrombosis and Haemostasis : JTH·M-P WinterI M Lang
Jan 17, 2020·PloS One·Luis Fernando BittarJoyce Maria Annichino-Bizzacchi
Mar 4, 2020·International Journal of Molecular Sciences·Subhradip MukhopadhyayRajabrata Sarkar
Jun 28, 2018·Journal of Thrombosis and Thrombolysis·Ji-Zheng QinChun Xia
Jul 2, 2019·Frontiers in Immunology·Subhradip MukhopadhyayToni M Antalis
Jul 14, 2019·Blood·Deya CherpokovaCharles N Serhan
Mar 15, 2020·International Journal of Molecular Sciences·Clemens GutmannAlberto Smith
Mar 22, 2020·International Journal of Molecular Sciences·J Matthew NicklasPeter K Henke
Feb 18, 2021·Journal of Thrombosis and Haemostasis : JTH·Peter K Henke, Andrea T Obi
Mar 19, 2021·Blood·Bram van Os, Esther Lutgens

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