Monocyte-specific Bcl-2 expression attenuates inflammation and heart failure in monocyte chemoattractant protein-1 (MCP-1)-induced cardiomyopathy.

Cardiovascular Research
Jianli NiuPappachan E Kolattukudy

Abstract

Infiltrating inflammatory cells within the myocardium have been shown to be apoptotic, but the significance of apoptotic inflammatory cells to the development of cardiomyopathy remains undefined. Transgenic mice with cardiac-specific expression of MCP-1 exhibit extensive apoptosis of infiltrating mononuclear cells and develop heart failure. Here, we tested the hypothesis that in vivo selective inhibition of apoptosis of infiltrating mononuclear cells would preserve cardiac structure and function and improve survival in this murine model. Mice with cardiac-specific expression of MCP-1 and monocyte-specific expression of Bcl-2 were generated by cross-breeding MCP-1 transgenic mice with hMRP8-Bcl-2 mice that over-express Bcl-2 in the monocytes. Structural and functional parameters and the inflammatory response of the heart were evaluated and compared between the wild-type and transgenic mice. Expression of Bcl-2 in monocytes results in superior preservation of myocardial structure, cardiac function and a significant prolongation of survival of MCP-1 transgenic mice. The beneficial effects of monocyte-specific Bcl-2 expression are associated with inhibition of apoptosis of infiltrating mononuclear cells, normalization of circulatin...Continue Reading

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Citations

Jan 9, 2007·Cardiovascular Research·Jianli NiuPappachan E Kolattukudy
May 26, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Misun ParkStephen F Vatner
Dec 21, 2007·PloS One·Anyela Camargo, Francisco Azuaje
Jul 2, 2009·Clinical Science·Jianli Niu, Pappachan E Kolattukudy
Jul 25, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Danbee KangJuhee Cho
Apr 21, 2020·Trends in Cell Biology·Stephen Jun Fei ChongShazib Pervaiz

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