Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-alpha secretion. Signal integration and NF-kappa B translocation

The Journal of Clinical Investigation
A S WeyrichG A Zimmerman

Abstract

Adhesion molecules that tether circulating leukocytes to endothelial cells may also transduce or modulate outside-in signals for cellular activation, providing an initial regulatory point in the inflammatory response. Adhesion of human monocytes to P-selectin, the most rapidly expressed endothelial tethering factor, increased the secretion of monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) by the leukocytes when they were stimulated with platelet-activating factor. Increased cytokine secretion was specifically inhibited by G1, an anti-P-selectin mAb that prevents P-selectin from binding to its ligand (P-selectin glycoprotein ligand-1) on myeloid cells. Moreover, tethering by P-selectin specifically enhanced nuclear translocation of nuclear factor-kappa B (NF-kappa B), a transcription factor required for expression of MCP-1, TNF-alpha, and other immediate-early genes. These results demonstrate that P-selectin, through its ligands on monocytes, may locally regulate cytokine secretion in inflamed tissues.

References

Mar 1, 1992·Immunology Today·G A ZimmermanT M McIntyre
Jul 1, 1992·The Journal of Cell Biology·K L MooreR P McEver
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A D YurochkoS Haskill
Feb 1, 1992·Immunological Investigations·H L EvanoffR M Strieter
Feb 1, 1991·The Journal of Cell Biology·K D PatelT M McIntyre
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C S WongM A Vadas
Feb 1, 1994·Current Opinion in Immunology·R P McEver
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·A CeliB Furie
Aug 1, 1993·The Journal of Clinical Investigation·D E LorantG A Zimmerman
Feb 1, 1993·The Journal of Cell Biology·R L Juliano, S Haskill

❮ Previous
Next ❯

Citations

May 16, 1997·International Journal of Cancer. Journal International Du Cancer·S A SolteszC Fisher
Apr 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E W Raines, R Ross
Aug 1, 1997·Basic Research in Cardiology·R J GuminaG J Gross
Apr 4, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Roberta Della BonaLuigi M Biasucci
Aug 6, 2011·Seminars in Immunopathology·Adriana Vieira-de-AbreuGuy A Zimmerman
Sep 10, 2005·European Journal of Applied Physiology·George A MiliasSmaragdi Antonopoulou
Apr 10, 2008·Journal of Thrombosis and Thrombolysis·Srinivas Iyengar, LeRoy E Rabbani
Feb 8, 2013·Current Heart Failure Reports·Paraskevi DetopoulouSmaragdi Antonopoulou
Feb 6, 2010·Immunologic Research·Barbara A Wasowska
Jan 15, 2004·Trends in Cardiovascular Medicine·Yuqing Huo, Klaus F Ley
Jun 19, 1998·Biochimica Et Biophysica Acta·I G De PlaenW Hsueh
Feb 1, 1997·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·T W WakefieldL J Greenfield
Dec 1, 1995·Seminars in Cell Biology·S Nourshargh, T J Williams
Nov 1, 2001·Trends in Cardiovascular Medicine·G K MaratheT M McIntyre
Sep 1, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·W M BaldwinR H Hruban
Jun 24, 1999·Cytokine & Growth Factor Reviews·E Van CoillieG Opdenakker
Nov 27, 2002·Vascular Pharmacology·Gopal K MaratheThomas M McIntyre
Apr 14, 2012·Molecular Pharmaceutics·Clinton F JonesDavid W Grainger
Jul 19, 2000·The Journal of Experimental Medicine·D I SimonJ A López
Sep 5, 2002·The Journal of Experimental Medicine·Sentot SantosoTriantafyllos Chavakis
Dec 10, 2002·Antioxidants & Redox Signaling·Toyoaki MuroharaTsutomu Imaizumi
Apr 11, 2000·Journal of Neurotrauma·Y Taoka, K Okajima
Jun 29, 1999·Transplantation·W M BaldwinF Sanfilippo
Feb 13, 2003·Current Opinion in Hematology·Thomas M McIntyreGuy A Zimmerman
Jul 6, 2012·Circulation. Cardiovascular Genetics·Pallav BhatnagarCraig A Fletcher
Jul 1, 2006·American Journal of Respiratory Cell and Molecular Biology·Charles ThompsonMarek Rola-Pleszczynski
May 1, 1995·The Journal of Clinical Investigation·D D Wagner
Mar 15, 1996·The Journal of Clinical Investigation·A S WeyrichG A Zimmerman
Jan 15, 1997·The Journal of Clinical Investigation·A Varki
Mar 1, 1997·The Journal of Clinical Investigation·R C JohnsonD D Wagner
May 15, 1997·The Journal of Clinical Investigation·H A LehrT M McIntyre
Dec 5, 2006·The Journal of Clinical Investigation·Alexander ZarbockKlaus Ley
Jul 3, 1998·The Journal of Clinical Investigation·Z M DongD D Wagner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.