Monocytes as effector cells: activated Ly-6C(high) mouse monocytes migrate to the lymph nodes through the lymph and cross-present antigens to CD8+ T cells

European Journal of Immunology
Patrícia LeiriãoCarlos Ardavín

Abstract

Monocytes have the capacity to differentiate into macrophages or dendritic cells (DCs) after extravasation into lymphoid and nonlymphoid tissues. They have thus been consequently considered as precursors, but not effector cells, recirculating exclusively through the blood. In this report, we demonstrate for the first time that, after subcutaneous injection, activated monocytes migrate through the lymphatics from the dermis into the draining lymph nodes by a CCR7-dependent mechanism. LPS-activated monocytes were less efficient than DCs in stimulating CD4(+) T cells, but unexpectedly, they were highly efficient in inducing antigen-specific CD8(+) T-cell proliferation by cross-presentation, both in vitro and in vivo. Interestingly, CD8(+) T cells stimulated in vivo by activated monocytes expressed a high level of CD62L, suggesting that they had undergone an unconventional activation process. In conclusion, our data strongly support the concept that monocytes can behave not only as precursor cells for macrophages and DCs, but also as effector cells with the capacity to migrate from the periphery to the lymph nodes through the lymph and to cross-present antigens to CD8(+) T cells. These results suggest that monocytes can play an imp...Continue Reading

References

Oct 22, 2003·The Journal of Experimental Medicine·Gianluca RottaMaria Rescigno
Feb 29, 2008·Annual Review of Immunology·Natalya V SerbinaEric G Pamer
Apr 2, 2008·Nature Reviews. Immunology·Reinhold FörsterAntal Rot
May 31, 2008·Cell·Shimon SakaguchiMasahiro Ono
Jan 10, 2009·Annual Review of Immunology·Cedric AuffrayFrederic Geissmann
Mar 18, 2009·Immunological Reviews·Sharon A Matthews, Doreen A Cantrell
Sep 23, 2009·Current Opinion in Hematology·Simon Yona, Steffen Jung
Nov 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Elodie SeguraJosé A Villadangos
Mar 3, 2010·Immunological Reviews·Pilar M Domínguez, Carlos Ardavín
Apr 14, 2010·Autoimmunity Reviews·Ravi K DineshRam Pyare Singh
Jun 15, 2011·Trends in Immunology·Molly A IngersollGwendalyn J Randolph

❮ Previous
Next ❯

Citations

May 8, 2013·Developmental and Comparative Immunology·B AlvarezC Revilla
May 24, 2014·Nature Reviews. Immunology·Florent Ginhoux, Steffen Jung
May 2, 2014·Frontiers in Immunology·Cynthia M FehresYvette van Kooyk
Jan 27, 2017·Annual Review of Immunology·Freidrich M CruzKenneth L Rock
Sep 9, 2017·International Journal of Cancer. Journal International Du Cancer·Florence FaureSebastian Amigorena
May 15, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mouldy SioudStein Sæbøe-Larssen
Oct 17, 2014·Immunological Reviews·Charlotte L ScottMartin Guilliams
Aug 1, 2020·Frontiers in Immunology·Elke M MuntjewerffGeert van den Bogaart
Jun 14, 2019·Frontiers in Immunology·Henry R Hampton, Tatyana Chtanova
Aug 9, 2016·The Journal of Pathology. Clinical Research·Madhur P MotwaniDerek W Gilroy
Nov 18, 2017·Nature Communications·Aránzazu Cruz-AdaliaEsteban Veiga
Aug 28, 2021·Cells·Arnolda Jakovija, Tatyana Chtanova
May 21, 2017·Advanced Drug Delivery Reviews·Kara L Spiller, Timothy J Koh

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

© 2021 Meta ULC. All rights reserved