Abstract
Monocytes have the capacity to differentiate into macrophages or dendritic cells (DCs) after extravasation into lymphoid and nonlymphoid tissues. They have thus been consequently considered as precursors, but not effector cells, recirculating exclusively through the blood. In this report, we demonstrate for the first time that, after subcutaneous injection, activated monocytes migrate through the lymphatics from the dermis into the draining lymph nodes by a CCR7-dependent mechanism. LPS-activated monocytes were less efficient than DCs in stimulating CD4(+) T cells, but unexpectedly, they were highly efficient in inducing antigen-specific CD8(+) T-cell proliferation by cross-presentation, both in vitro and in vivo. Interestingly, CD8(+) T cells stimulated in vivo by activated monocytes expressed a high level of CD62L, suggesting that they had undergone an unconventional activation process. In conclusion, our data strongly support the concept that monocytes can behave not only as precursor cells for macrophages and DCs, but also as effector cells with the capacity to migrate from the periphery to the lymph nodes through the lymph and to cross-present antigens to CD8(+) T cells. These results suggest that monocytes can play an imp...Continue Reading
References
Oct 22, 2003·The Journal of Experimental Medicine·Gianluca RottaMaria Rescigno
Apr 7, 2007·Immunity·Beatriz LeónCarlos Ardavín
Feb 29, 2008·Annual Review of Immunology·Natalya V SerbinaEric G Pamer
Apr 2, 2008·Nature Reviews. Immunology·Reinhold FörsterAntal Rot
Apr 9, 2008·Nature Immunology·Linda V SinclairDoreen A Cantrell
May 31, 2008·Cell·Shimon SakaguchiMasahiro Ono
Jan 10, 2009·Annual Review of Immunology·Cedric AuffrayFrederic Geissmann
Mar 18, 2009·Immunological Reviews·Sharon A Matthews, Doreen A Cantrell
Sep 23, 2009·Current Opinion in Hematology·Simon Yona, Steffen Jung
Nov 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Elodie SeguraJosé A Villadangos
Mar 3, 2010·Immunological Reviews·Pilar M Domínguez, Carlos Ardavín
Apr 14, 2010·Autoimmunity Reviews·Ravi K DineshRam Pyare Singh
Oct 30, 2010·Cell·Cheolho CheongRalph M Steinman
Jun 15, 2011·Trends in Immunology·Molly A IngersollGwendalyn J Randolph
Aug 30, 2011·European Journal of Immunology·Pilar M DomínguezCarlos Ardavín
Citations
May 8, 2013·Developmental and Comparative Immunology·B AlvarezC Revilla
May 24, 2014·Nature Reviews. Immunology·Florent Ginhoux, Steffen Jung
Oct 19, 2013·Veterinary Research·Petra OndrackovaMartin Faldyna
May 2, 2014·Frontiers in Immunology·Cynthia M FehresYvette van Kooyk
Feb 24, 2012·PloS One·Felicity C StarkLakshmi Krishnan
May 12, 2011·PloS One·Annalisa CiabattiniDonata Medaglini
Mar 13, 2014·PloS One·Suzanne T Nizza, James J Campbell
Sep 14, 2016·Frontiers in Immunology·Hege LundAnne K Storset
Jan 27, 2017·Annual Review of Immunology·Freidrich M CruzKenneth L Rock
Jan 13, 2018·Journal of Cellular Physiology·Yang ZhaoYong Zhao
Jun 15, 2017·Acta Haematologica·Yanan CaiYuansong Bai
Sep 9, 2017·International Journal of Cancer. Journal International Du Cancer·Florence FaureSebastian Amigorena
May 15, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mouldy SioudStein Sæbøe-Larssen
Oct 17, 2014·Immunological Reviews·Charlotte L ScottMartin Guilliams
Oct 16, 2015·European Journal of Immunology·Shivajanani SivakumaranClare L Bennett
Aug 1, 2020·Frontiers in Immunology·Elke M MuntjewerffGeert van den Bogaart
Jun 14, 2019·Frontiers in Immunology·Henry R Hampton, Tatyana Chtanova
Aug 9, 2016·The Journal of Pathology. Clinical Research·Madhur P MotwaniDerek W Gilroy
Nov 18, 2017·Nature Communications·Aránzazu Cruz-AdaliaEsteban Veiga
Jul 22, 2017·Scientific Reports·S De KokerJ Grooten
Nov 8, 2014·Cancer Research·Caglar CekicJoel Linden
Nov 27, 2020·IScience·Katherine G BirminghamSusan N Thomas
Feb 14, 2021·Science Immunology·Joseph M LealMichael Y Gerner
Apr 11, 2021·Cellular Immunology·Manfred B Lutz, Ina N Eckert
Aug 28, 2021·Cells·Arnolda Jakovija, Tatyana Chtanova
May 21, 2017·Advanced Drug Delivery Reviews·Kara L Spiller, Timothy J Koh