Monocytes stimulated with group B streptococci or interferons release tumour necrosis factor-related apoptosis-inducing ligand

Scandinavian Journal of Immunology
O HalaasT Espevik

Abstract

Tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a cytotoxic member of the TNF family. Some reports have shown that TRAIL is released from cells in a soluble form. In this work, we have investigated the mechanism of release of TRAIL from monocytes. First, we show that whole gram-positive, gram-negative and mycoplasmal bacteria as well as lipopolysaccharide (LPS), interferon-alpha (IFN-alpha), -beta and -gamma all induced upregulation of TRAIL on the surface of human monocytes. Next, we show that IFN-alpha, -beta and -gamma all induced a dose-dependent release of TRAIL, giving significant amounts of soluble TRAIL after 2 days. Of the bacteria, only the Group B streptococcus COH-1 (GBS) induced release of TRAIL and concomittantly induced IFN-alpha. Monocytes stimulated with GBS or IFN-alpha also showed extensive cell death. When monocyte apoptosis was prevented by interleukin-1, GM-CSF, LPS or the caspase inhibitor zVADfmk, the IFN-alpha-induced release of TRAIL was reduced, whereas agents inducing necrosis caused increased release of TRAIL. LPS also prevented release of TRAIL from GBS-stimulated monocytes. The release of TRAIL from IFN-alpha-stimulated monocytes was reduced by inhibitors of both cysteine...Continue Reading

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Citations

Feb 1, 2011·Archives of Dermatological Research·Sandra PeternelMarija Kaštelan
Jul 25, 2003·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Sameer JunnarkarChee V Soong
Sep 28, 2005·The Journal of Investigative Dermatology·Ekatherina VassinaDagmar Simon
Oct 8, 2008·Immunological Reviews·Julia Wennekamp, Philipp Henneke
Aug 19, 2004·Journal of Neuroinflammation·Tammy Kielian
Aug 7, 2009·Autoimmunity·Mariana J Kaplan
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seija LehnardtPhilipp Henneke

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