Monocytic Angiotensin and Endothelin Receptor Imbalance Modulate Secretion of the Profibrotic Chemokine Ligand 18

The Journal of Rheumatology
Judith RademacherGabriela Riemekasten

Abstract

To assess monocytic expression and ratio of angiotensin and endothelin receptors in systemic sclerosis (SSc) and their functional relevance. Receptor expression was measured by flow cytometry. Chemokine ligand 18 (CCL18) concentration in supernatants of peripheral blood mononuclear cells stimulated with immunoglobulin G was measured by ELISA. Monocytes of patients with SSc presented an increased angiotensin II Type 1 receptor (AT1R)/AT2R ratio compared with those of healthy donors. Patients with lung fibrosis and patients with high modified Rodnan skin score showed a reduced endothelin 1 Type A receptor (ETAR)/ETBR ratio. High AT1R/AT2R, but low ETAR/ETBR ratios corresponded to higher CCL18 secretion. Altered angiotensin and endothelin receptor ratios observed in SSc influence autoantibody-mediated effects such as secretion of profibrotic CCL18.

References

Oct 28, 1999·Cardiovascular Research·G P RossiA C Pessina
Jun 14, 2003·American Journal of Respiratory Cell and Molecular Biology·Sergei P AtamasBarbara White
Dec 13, 2005·The FEBS Journal·Angelika HorstmeyerThomas Krieg
May 1, 2007·Arthritis and Rheumatism·Antje PrasseJoachim Müller-Quernheim
Apr 2, 2009·European Journal of Clinical Investigation·X ShiwenC Fonseca
Nov 18, 2010·Annals of the Rheumatic Diseases·Gabriela RiemekastenDuska Dragun
May 3, 2014·The European Respiratory Journal·Jonas SchuppAntje Prasse
Oct 11, 2014·Clinical and Experimental Immunology·Y Chang, W Wei

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Citations

Sep 1, 2017·Nature Reviews. Rheumatology·Otavio Cabral-Marques, Gabriela Riemekasten
Mar 16, 2017·Clinical Rheumatology·Alain LescoatPatrick Jégo
Jun 18, 2017·Frontiers in Immunology·Ralf J LudwigFalk Nimmerjahn

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