PMID: 16612453Apr 14, 2006Paper

Monocytosis is an independent risk marker for coronary artery disease

Arquivos brasileiros de cardiologia
Abrahão Afiune NetoJosé Antonio F Ramires

Abstract

Inflammation and activation of immune system cells play an important role in the pathogenesis of atherosclerosis. This study analyzes the white blood count, including neutrophils, eosinophils, lymphocytes, monocytes and basophils, of patients with chronic coronary artery disease (CAD) and acute myocardial infarction (AMI). The white blood cell count was analyzed in 232 patients without diabetes between the ages of 15 and 88. One hundred and forty-two patients were angiographically diagnosed with CAD (57 with stable CAD and 85 with AMI) and compared to 90 control individuals. The control and CAD groups were similar in respect to age, body mass index, family history, smoking habits, hypertension, HDL and LDL (all variables with p > 0.25). The univariate analysis revealed a higher prevalence of leukocytosis in the CAD group, which in turn was higher in the AMI patients than the stable CAD patients. The same trend was observed for monocytes. However, the distribution of all other cells in the complete blood count (CBC) was similar. Multivariate analysis using the logistic regression method with the stepwise (all variables) and backward models (p < 0.25), showed that monocytosis was an independent variable for CAD and AMI. The numbe...Continue Reading

Citations

Aug 19, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Arif ArısoyÇağrı Zorlu
Mar 14, 2019·European Journal of Preventive Cardiology·Xueyan ZhaoJinqing Yuan
Jan 4, 2007·The Journal of Clinical Investigation·Filip K SwirskiMikael J Pittet
Nov 9, 2019·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Reem Al-RashoudiIsabel J Crane
Jul 3, 2021·International Journal of Molecular Sciences·Vilbert SikorskiEsko Kankuri
Apr 7, 2011·Journal of Immunological Methods·W L BreslinB K McFarlin

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