Monohydroperoxidized fatty acids but not 4-hydroxynonenal induced acute cardiac cell damage

Free Radical Biology & Medicine
J P IliouJ P Vilaine

Abstract

Unsaturated fatty acids constitutive of cardiac membranal lipid matrix are one of the primary targets for reactive oxygen species generated during ischemia-reperfusion cycle. Lipid peroxidation is a cascade of intricate reactions involving the successive formations of fatty acids hydroperoxides and aldehydic compounds such as alkenals derived from the oxidative fragmentation of these hydroperoxides. The potential deleterious effects of different classes of lipid peroxidation products on cardiac cells were compared using three in vitro approaches: (i) cardiomyocyte integrity, (ii) electromechanical activity of papillary muscle, and (iii) atrial contractility. The following products of lipid peroxidation were tested: (i) photoperoxidized arachidonic acid pooling hydroperoxidized derivatives and aldehydic compounds, (ii) fatty acids hydroperoxides, and (iii) 4-hydroxynonenal, a characteristic alkenal derived from the oxidative fragmentation of hydroperoxidized n-6 fatty acids. Only fatty acids hydroperoxides induced drastic loss of cellular integrity and severe disturbances in electromechanical activity of cardiomyocytes. 4-hydroxynonenal induced only a slight leak of lactate dehydrogenase at high concentrations and did not modify...Continue Reading

References

Sep 1, 1992·Journal of Cardiovascular Pharmacology·C BreugnotA Lenaers
Nov 16, 1992·Biochimica Et Biophysica Acta·G YuanN Yamazaki
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J FruebisD Steinberg
Feb 14, 1992·Archives of Biochemistry and Biophysics·C M Dhanbhoora, J R Babson
Oct 1, 1991·Cardiovascular Drugs and Therapy·D J Hearse
Oct 1, 1991·Cardiovascular Drugs and Therapy·R BolliR S Rabinovitz
Oct 1, 1991·Cardiovascular Drugs and Therapy·E Marban
Jan 1, 1991·Free Radical Biology & Medicine·H EsterbauerH Zollner
Apr 1, 1990·Cell Biology International Reports·L Ver DonckM Borgers
Sep 1, 1988·Journal of Cardiovascular Pharmacology·H H KleinH Kreuzer
Sep 7, 1989·Molecular and Cellular Biochemistry·P A Poole-Wilson
Mar 21, 1986·Biochimica Et Biophysica Acta·H EsterbauerM Comporti
Jul 1, 1988·Journal of Molecular and Cellular Cardiology·G J van der VusseR S Reneman
Jan 1, 1986·Cardiovascular Research·A van der LaarseC H Bloys van Treslong
May 1, 1994·Cardiovascular Research·H S Silverman, M D Stern
Feb 10, 1993·Biochimica Et Biophysica Acta·R Ferrari-IliouP Mazliak
Oct 1, 1993·European Journal of Pharmacology·J P IliouJ P Vilaine

❮ Previous
Next ❯

Citations

Feb 9, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·Waldemar M PrzybyszewskiOlena Palyvoda
Apr 27, 2001·Mechanisms of Ageing and Development·G Spiteller
Aug 30, 2001·Experimental Gerontology·G Spiteller
Nov 7, 2000·Free Radical Biology & Medicine·I DurotP Athias
Mar 13, 2014·Cardiovascular Toxicology·María P Hortigón-Vinagre, Fernando Henao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.