PMID: 11604060Oct 18, 2001Paper

Monohydroxylated fatty acid content in peripheral blood mononuclear cells and immune status of people at long times after the Chernobyl accident

Radiation Research
A ChumakA F Prigent

Abstract

The monohydroxylated fatty acid content of peripheral blood mononuclear cells from 23 cleanup workers and 16 unexposed individuals was studied in relation to their immune status after the Chernobyl accident. Men with absorbed doses below 0.32 Gy showed higher levels of free and esterified 12-hydroxyeicosatetraenoic acid (12-HETE) than unexposed men, whereas 15-HETE and the 17-hydroxy derivative of C22 fatty acid (17-OH 22), either free or esterified in phospholipids, were increased in a dose-dependent manner. The percentage of CD4-positive cells was also increased significantly in heavily irradiated men, whereas the percentage of CD8-positive cells tended to decrease with dose. Furthermore, the absolute count of CD4-positive cells was correlated positively with the amount of esterified 15-HETE in the phospholipid fraction of the mononuclear cells and with the total 15-HETE. These results show for the first time that the accumulation of autoxidized/lipoxygenase products of polyunsaturated fatty acids in the mononuclear cells of irradiated individuals was associated with immune imbalance. This may be the basis for certain late effects of radiation such as autoimmune disorders, somatic and neoplastic diseases, and early aging.

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D J ConradE Sigal
Nov 1, 1990·Scandinavian Journal of Immunology·E MoritaE Christophers
Nov 19, 1989·Molecular and Cellular Biochemistry·S K SrivastavaA Bhatnagar
Jan 1, 1988·Progress in Lipid Research·A A SpectorS A Moore
Jan 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·I K KolomiytsevaA M Kuzin
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Oct 1, 1995·Molecular Carcinogenesis·P KriegG Fürstenberger
Jul 30, 1993·Biochemical and Biophysical Research Communications·P W Tebbey, T M Buttke
Jul 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D Schlondorff
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R J SmithJ E Bleasdale
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·D G TangK V Honn
Feb 5, 1999·Leukemia Research·K M AndersonJ E Harris
Mar 23, 1999·Advances in Experimental Medicine and Biology·T ScheweS Nigam
Apr 10, 1999·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·M Pollycove, L E Feinendegen
Nov 13, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·M K PatriciaC C Hedrick
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·C D Funk, X S Chen
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·M C JoinerI Turesson

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Citations

Nov 20, 2012·Journal of Applied Toxicology : JAT·Nicholas SynhaeveJean-Marc Bertho
Mar 30, 2010·Toxicology and Industrial Health·M R Sheikh SajjadiehV B Bojenko
Nov 8, 2005·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Konstantin N LoganovskyPierre Flor-Henry
Feb 25, 2011·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Jean-Marc BerthoIsabelle Dublineau
Feb 29, 2020·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Jean-Marc BerthoKarine Tack
Dec 29, 2020·Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï·H V KosiakovaA A Chumak

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