Monoliths in capillary electrochromatography and capillary liquid chromatography in conjunction with mass spectrometry

Electrophoresis
Dana MoravcováSusanne K Wiedmer

Abstract

Here, we have reviewed separation studies utilizing monolithic capillary columns for separation of compounds preceding MS analysis. The review is divided in two parts according to the used separation method, namely CEC and capillary LC (cLC). Based on our overview, monolithic CEC-MS technique have been more focused on the syntheses of highly specialized and selective separation phase materials for fast and efficient separation of specific types of analytes. In contrast, monolithic cLC-MS is more widely used and is often employed, for instance, in the analysis of oligonucleotides, metabolites, and peptides and proteins in proteomic studies. While poly(styrene-divinylbenzene)-based and silica-based monolithic capillaries found their place in proteomic analyses, the other laboratory-synthesized monoliths still wait for their wider utilization in routine analyses. The development of new monolithic materials will most likely continue due to the demand of more efficient and rapid separation of increasingly complex samples.

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Citations

Nov 4, 2016·Journal of Separation Science·Ivan Mikšík
Mar 16, 2017·Analytical and Bioanalytical Chemistry·Susana Meseguer-LloretJosé M Herrero-Martínez
Aug 24, 2017·Electrophoresis·Mariia V VolokitinaEvgenia G Korzhikova-Vlakh
Sep 15, 2017·Electrophoresis·Uroš AndjelkovićMilica Popović
Sep 15, 2019·Analytica Chimica Acta·María Vergara-BarberánJosé Manuel Herrero-Martínez

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