Monomer-coated very small superparamagnetic iron oxide particles as contrast medium for magnetic resonance imaging: preclinical in vivo characterization

Investigative Radiology
Susanne WagnerMatthias Taupitz

Abstract

Preclinical in-vivo characterization of a newly developed MR contrast medium consisting of very small superparamagnetic iron oxide particles (VSOP) coated with citrate (VSOP-C184). VSOP-C184 (core diameter: 4 nm; total diameter: 8.6 nm; relaxivities in water at 0.94 T (T1) 20.1 and (T2) 37.1 l/[mmol*sec]) was investigated to determine its pharmacokinetics, efficacy, acute single dose toxicity, repeated dose toxicity, and genotoxicity. The plasma elimination half-life at 0.045 mmol Fe/kg was 21.3 +/- 5.5 minutes in rats and 36.1 +/- 4.2 minutes in pigs, resulting in a T1-relaxation time of plasma of < 100 milliseconds for 30 minutes in pigs. The particles are mainly cleared via the phagocytosing system of the liver. MR angiography at a dose of 0.045 mmol Fe/kg shows an excellent depiction of the thoracic and abdominal vasculature in rats and of the coronary arteries in pigs. The LD50 in mice is > 17.9 mmol Fe/kg. A good tolerance and safety profile was found. The experiments indicate, that VSOP-C184 may be a well tolerated and safe contrast medium for MR imaging that can be effectively used for MR angiography including visualization of the coronary arteries.

References

Jan 1, 1989·AJR. American Journal of Roentgenology·R WeisslederJ Lewis
Jul 1, 1973·Mutation Research·M von Ledebur, W Schmid
May 1, 1983·Mutation Research·D M Maron, B N Ames
Jan 1, 1993·Magnetic Resonance Imaging·B K SchafferR Weissleder
Apr 1, 1995·Journal of Vascular Surgery·M R PrinceK J Cho
May 1, 1994·Journal of Magnetic Resonance Imaging : JMRI·S J McLachlanA Y Olukotun
May 1, 1994·Journal of Magnetic Resonance Imaging : JMRI·J C BöckR Felix
Jan 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E C WienerP C Lauterbur
Jul 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·J W BulteJ A Frank
Jan 1, 1997·Journal of Magnetic Resonance Imaging : JMRI·Y AnzaiS J McLachlan
May 13, 1998·Radiology·R B LaufferR C Walovitch
Jun 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D LiR B Lauffer
Jun 17, 1998·Journal of Magnetic Resonance Imaging : JMRI·M R EngelbrechtC B Higgins
Dec 3, 1998·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·R M MoscatiJ Mayrose
Mar 17, 1999·Journal of Magnetic Resonance Imaging : JMRI·A M TaylorD J Pennell
May 8, 1999·Journal of Magnetic Resonance Imaging : JMRI·L O JohanssonC H Lorenz
Oct 3, 1999·Journal of Magnetic Resonance Imaging : JMRI·C BremerP Reimer
Nov 5, 1999·Journal of Magnetic Resonance Imaging : JMRI·M StuberW J Manning
Jun 22, 2000·Journal of Magnetic Resonance Imaging : JMRI·T H HelbichR C Brasch
Oct 26, 2000·Journal of Magnetic Resonance Imaging : JMRI·J SchnorrB Hamm

❮ Previous
Next ❯

Citations

Jun 7, 2005·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zefeng XiaYuan Tian
Dec 26, 2006·Der Radiologe·J GrimmR Weissleder
Jan 5, 2007·Der Radiologe·L MatuszewskiC Bremer
Mar 8, 2008·Basic Research in Cardiology·David E SosnovikRalph Weissleder
Feb 24, 2006·Annals of Biomedical Engineering·Daniel L J ThorekAndrew Tsourkas
Sep 29, 2011·Nature Reviews. Clinical Oncology·Moritz F KircherJan Grimm
Oct 23, 2009·Journal of the Royal Society, Interface·Eyk Schellenberger
Jul 24, 2012·Radiology·Moritz F Kircher, Jürgen K Willmann
Sep 24, 2015·Bioprocess and Biosystems Engineering·Fei DengXiaojun Ma
Jun 6, 2014·BioMed Research International·Samer Hasan Hussein-Al-AliMohd Zobir Hussein
May 10, 2012·Cell Adhesion & Migration·Miriam KaminskiJana Glumm
Dec 10, 2016·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Yuske KobayashiMatthias Taupitz
Jan 31, 2017·Nanomedicine : Nanotechnology, Biology, and Medicine·Dominique BerndtCarmen Infante-Duarte
Sep 22, 2015·Chemical Society Reviews·Hamed AramiKannan M Krishnan
Jan 8, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·L GutiérrezM P Morales
Nov 25, 2003·Investigative Radiology·Val M Runge
Apr 13, 2004·Investigative Radiology·Egidijus Uzgiris
Sep 28, 2012·International Journal of Cancer. Journal International Du Cancer·Subrata K GhoshZdravka Medarova
Apr 18, 2007·Circulation·David E SosnovikRalph Weissleder
Mar 23, 2011·Circulation. Cardiovascular Imaging·Marcus R MakowskiRene M Botnar
Jun 24, 2009·Nature Reviews. Endocrinology·Zdravka Medarova, Anna Moore
Jul 1, 2011·Nanoscale·Morteza MahmoudiSophie Laurent
Apr 7, 2012·Chemical Society Reviews·Miriam ColomboWolfgang J Parak
Sep 6, 2013·Journal of Magnetic Resonance Imaging : JMRI·Andrea ProttiAjay M Shah
Sep 7, 2019·Nanotechnology·Kai WuJian-Ping Wang
Nov 26, 2002·Investigative Radiology·Val M Runge

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.