Mononeuritis multiplex in diabetes mellitus: evidence for underlying immune pathogenesis

Journal of Neurology, Neurosurgery, and Psychiatry
P Kelkar, G J Parry

Abstract

Four patients with type 2 diabetes mellitus developed mononeuritis multiplex subacutely. Sural nerve biopsies showed multifocal axonal loss in all patients, with epineurial perivascular inflammation affecting small calibre vessels in three. Three patients improved with immunotherapy. These observations suggest that mononeuritis multiplex in diabetes may be caused by an immune mediated vasculopathy and that it is pathogenetically akin to the more common and better recognised diabetic amyotrophy.

Citations

Oct 25, 2006·The Nursing Clinics of North America·Geralyn R Spollett
Apr 24, 2004·Journal of the Peripheral Nervous System : JPNS·Yusuf A RajaballyRichard J Abbott
May 10, 2016·Muscle & Nerve·Dinkar KulshreshthaNuzhat Husain
Jan 12, 2020·BMJ Case Reports·Jonathan Seung Doe Na, Philip C Dittmar
Jun 27, 2020·Muscle & Nerve·Kamakshi PatelEzgi Tiryaki
May 14, 2021·Tremor and Other Hyperkinetic Movements·Ritwik GhoshJulián Benito-León
Nov 10, 2021·Expert Review of Clinical Immunology·Norman Latov

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