PMID: 3213431Jan 1, 1988Paper

Mononuclear cell infiltrate and HLA-DR expression in low grade astrocytomas. An immunohistological study of 23 cases

Acta Neuropathologica
M L RossiT H Moss

Abstract

Frozen samples from 23 low grade (grade I and II) astrocytomas were studied by means of a panel of monoclonal antibodies to macrophages, lymphocytes (and their subsets) and HLA-DR antigens. Macrophages were present in low to moderate numbers in 38%-86% of cases, the variance in figures depending on the antibody used. T lymphocytes, the majority of CD8 phenotype, were detected in low numbers in 78% of tumours. B lymphocytes were scanty in 22% (5/22) and totally absent in the remaining cases. HLA-DR antigen was expressed by tumour cells in 35% (6/17) of cases. These findings indicate that in some low grade astrocytomas there is a mononuclear cell infiltrate with macrophages and secondarily CD8+ lymphocytes playing the major role. The significance of these findings remains speculative at present.

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Citations

Jan 1, 1992·Acta Neuropathologica·N OharaT Akagi
Jan 1, 1989·Acta Neuropathologica·M L RossiH B Coakham
Jan 1, 1996·Acta neurochirurgica·B GiomettoB Tavolato
Feb 1, 1989·Research in Immunology·R A Sobel
Mar 1, 2000·Journal of Neuroimmunology·A R DixL A Morford
Mar 1, 1991·Pathology, Research and Practice·M L RossiH B Coakham
Dec 1, 1992·Neuropathology and Applied Neurobiology·L BøH Nyland
Aug 15, 1998·Annals of the New York Academy of Sciences·L Lorusso, M L Rossi
Mar 1, 1991·Journal of Neurosurgery·H G KrouwerM Prados
Aug 1, 1992·Journal of Neurosurgery·J SchneiderD R Hinton
Jan 1, 2010·Cancers·Alfredo ContiM'hammed Aguennouz
Jun 17, 2005·Journal of Neuroscience Research·Jyoti J WattersBehnam Badie
Oct 11, 2005·Journal of Neuropathology and Experimental Neurology·Hervé HuangHiroko Ohgaki
Oct 16, 2002·Glia·Manuel B GraeberGeorg W Kreutzberg

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