PMID: 8967489May 1, 1996Paper

Mononuclear cells and cytokines stimulate gastrin release from canine antral cells in primary culture

The American Journal of Physiology
F S LehmannA H Soll

Abstract

Patients with Helicobacter pylori-associated gastritis have an increased release of gastrin. The mechanisms by which H. pylori affects the endocrine cells are unclear. We have used primary cultures containing canine antral G cells to examine the effects of human blood mononuclear cells, purified monocytes and lymphocytes, recombinant cytokines, and NH4Cl on gastrin release. Mononuclear cells and purified monocytes in direct contact with G cells stimulated gastrin release dose dependently. Separating mononuclear cells from G cells by Transwell filters with 0.4-micron pore size still produced a significant increase of gastrin release. Three human recombinant cytokines, interferon-gamma, tumor necrosis factor-alpha, and interleukin-2, but not interleukin-6 and interleukin-1 beta, each produced dose-dependent increases of gastrin stimulation. NH4Cl did not stimulate gastrin release. We conclude that mononuclear cells and purified monocytes prepared from human blood, as well as several cytokines, stimulate gastrin release from antral G cells. These factors may play an important role in the pathogenesis of H. pylori-associated hypergastrinemia.

Citations

Feb 22, 2001·Annual Review of Physiology·G J DockrayT Wang
Jul 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Frank Serge LehmannChristoph Beglinger
Oct 4, 2014·World Journal of Gastroenterology : WJG·Yun ShaoWei-Hao Sun

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