PMID: 6165307Jan 1, 1980Paper

Mononuclear phagocytes: responders to and producers of interferon

Annals of the New York Academy of Sciences
S I HamburgM Rabinovitch

Abstract

We have provided evidence that in vivo-induced type I IF enhanced Fc-mediated particle uptake by mouse macrophages. Fc-mediated phagocytosis of opsonized erythrocytes by unelicited fresh or cultivated macrophages was stimulated by 4-8 hours of cultivation with 100 ohms/ml IF. A 1-hour pulse was sufficient when followed by incubation in If-free medium. Pactamycin, a protein synthesis inhibitor, and camptothecin, and RNA synthesis inhibitor, blocked the stimulation of phagocytosis, indicating a requirement for macromolecular synthesis. Binding by the macrophages of a radioiodinated monoclonal antibody with anti-Fc receptor II specificity indicated that the stimulation of phagocytosis did not result from an increase in the numbers of available Fc receptors. Inflammatory macrophages, while more phagocytic than resting cells, could be further stimulated by IF in vitro, as could macrophages stimulated with LPS. In contrast, macrophages obtained from animals treated with IF inducers could not be further stimulated by IF. LPS-prestimulated and normal macrophages showed similar time-course and dose-response curves to IF, indicating that the probable mechanism of stimulation is similar in both types of cells. Cultivated bone marrow-deriv...Continue Reading

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Citations

Jan 1, 1991·Folia Microbiologica·V VĕtvickaM Bilej
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J SchneckB R Bloom
Mar 1, 1984·The Journal of Experimental Medicine·L P SvederskyM A Palladino
May 11, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·P K VadivelooJ A Hamilton
Jan 1, 1982·Journal of Interferon Research·J W ScottM R Proffitt
Jan 1, 1985·Comparative Immunology, Microbiology and Infectious Diseases·A Ryter
Aug 1, 1986·Microbial Pathogenesis·D A WeigentS Baron
Aug 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·V VĕtvickaI Miler
May 1, 1983·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·C Lavelle, K Vijayaraghavan
Jun 1, 1988·Journal of Interferon Research·V LackovicJ Rovenský
Jan 1, 1984·Folia Microbiologica·L Fornůsek, V Vĕtvicka
May 1, 1988·European Journal of Immunology·V PancréC Auriault
Feb 1, 1983·Human Pathology·A Lasser

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