Mononucleotide recognition by cyclic trinuclear palladium(II) complexes containing 4,7-phenanthroline N,N bridges

Dalton Transactions : an International Journal of Inorganic Chemistry
Miguel A GalindoMiguel Quirós

Abstract

Reaction of [(dach)Pd(NO3)2] entities (dach = (R,R)-1,2-diaminocyclohexane, (S,S)-1,2-diaminocyclohexane) and 4,7-phenanthroline (phen) providing, respectively, 90 and 120 degrees bond angles, leads to the formation of two novel positively charged homochiral cyclic trinuclear metallacalix[3]arene species [((R,R)-1,2-diaminocyclohexane)Pd(phen)]3(NO3)6 (2a) and [((S,S)-1,2-diaminocyclohexane)Pd(phen)]3(NO3)6 (2b). These species have been characterised by 1)H NMR and X-ray diffraction methods (2b), showing that they possess accessible cavities suited for supramolecular recognition processes. We prove, indeed, from 1H NMR studies the inclusion of mononucleotides inside the cavity of the trinuclear species [(ethylenediamino)Pd(phen)]3(6+) (1), [((R,R)-1,2-diaminocyclohexane)Pd(phen)]3(6+) (2a) and [((S,S)-1,2-diaminocyclohexane)Pd(phen)]3(6+) (2b) in aqueous solution. Association constants (K(ass)) range from 85 +/- 6 M(-1) for the interaction between [(ethylenediamine)Pd(phen)]3(6+) and adenosine monophosphate to 37 +/- 4 M(-1) for the interaction between [(1,2-diaminocyclohexane)Pd(phen)]3(6+) and thymidine monophosphate. We invoke the synergy of electrostatic, anion-pi and pi-pi interactions to explain the recognition of mononuc...Continue Reading

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Citations

Aug 8, 2008·Chemical Communications : Chem Comm·Miguel A GalindoJorge A R Navarro
Jul 16, 2010·Bioinorganic Chemistry and Applications·Anupam KhutiaBernhard Lippert
Mar 6, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Mamina BholMalaichamy Sathiyendiran
Oct 10, 2007·Angewandte Chemie·Andreas SteffenHans-Georg Stammler
Mar 21, 2007·Angewandte Chemie·Gennady V OshovskyWillem Verboom
Dec 17, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Maria Michela Dell'annaMaurizio Peruzzini
Jul 5, 2005·Dalton Transactions : an International Journal of Inorganic Chemistry·Sheng-Hui LiKentaro Yamaguchi
Aug 24, 2010·Chemical Society Reviews·Danaboyina RamaiahRekha R Avirah
Dec 11, 2008·Chemical Reviews·Ennio ZangrandoEnzo Alessio
May 25, 2018·Inorganic Chemistry·Kentaro AokiHiroshi Kitagawa

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