PMID: 8583097Dec 1, 1995Paper

Monophasic luminal release of prostaglandin E2 in patients with reflux esophagitis under the impact of acid and acid/pepsin solutions. Its potential pathogenetic significance

Journal of Clinical Gastroenterology
M MarcinkiewiczR W McCallum

Abstract

Normal human esophageal mucosa exhibits biphasic secretory responses to intraluminal stimuli in terms of PGE2 release with a decline under the impact of HCl and an increase in PGE2 release during mucosal exposure to HCl/Pepsin. PGE2 secretory patterns in patients with reflux esophagitis (RE) remain unknown. We have studied, therefore, luminal release of PGE2 in 28 patients with nonhealed and healed RE, and compared the obtained results with corresponding values recorded in controls. The rate of luminal release of PGE2 in nonhealed RE exhibited a monophasic patterns, i.e., significantly decreased both during mucosal exposure to HCl (2,273 +/- 444, vs. 3,655 +/- 600 pg/min, p = 0.025) and HCl/pepsin (1,271 +/- 244, vs. 3,655 +/- 600 pg/min. p = 0.003) as compared to its basal value. However, the rate of luminal PGE2 release in patients with nonhealed RE in basal conditions and during mucosal exposure to HCl was significantly higher than corresponding values in controls. Luminal release of PGE2 in patients with healed endoscopic esophagitis was significantly lower as compared to corresponding values recorded in patients with nonhealed endoscopic changes and in controls. In conclusion, (a) monophasic inhibitory responses of the eso...Continue Reading

Citations

Jun 27, 2000·Prostaglandins & Other Lipid Mediators·J D Long, R C Orlando
Mar 3, 1998·Journal of Pediatric Gastroenterology and Nutrition·A ZicariS Cucchiara
Aug 21, 2002·Journal of Pediatric Gastroenterology and Nutrition·Yvan Vandenplas, Eric Hassall
Oct 27, 1998·Current Medical Research and Opinion·M MarcinkiewiczE Czyzewska
Feb 4, 1998·Baillière's Clinical Gastroenterology·M Thomson
Sep 27, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·J Sarosiek, R W McCallum
Apr 21, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Marek MajewskiJerzy Sarosiek
Aug 11, 2005·Canadian Journal of Physiology and Pharmacology·Michelle L SeymourWallace K MacNaughton
Nov 9, 2011·Nature Reviews. Gastroenterology & Hepatology·Yaron Niv, Ronnie Fass

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