PMID: 70229May 26, 1977Paper

Monosialoganglioside liposome-entrapped enzyme uptake by hepatic cells

Biochimica Et Biophysica Acta
A Surolia, B K Bachhawat

Abstract

Monosialoganglioside liposomes are rapidly taken up by the liver as compared to dicetylphosphate, phosphatidic acid or neutral liposomes. Asialoganglioside GM 1 liposomes are taken up with the same avidity as ganglioside GM 1 liposomes. Competition experiments with asialofetuin suggest that this uptake is mediated by specific recognition of the terminal galactose residues of the glyco-lipid liposomes by the receptor present on the plasma membrane of the parenchymal cells of liver. Thus liposomes containing glycolipids with terminal beta-galactosyl residues should provide an approach for specifically directing biologically active molecules to liver parenchymal cells.

References

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Jan 1, 1975·Biochemical Society Transactions·G Gregoriadis
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Aug 15, 2013·Journal of Animal Science·A M Loaiza-EcheverriM Henry

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Citations

Jan 1, 1988·Free Radical Biology & Medicine·S N Chatterjee, S Agarwal
Mar 28, 2013·Journal of Drug Delivery·Stefano Salmaso, Paolo Caliceti
Nov 15, 1983·Biochemical Pharmacology·C F GotfredsenA Goethals
Mar 21, 1977·Biochemical and Biophysical Research Communications·S Pillai, B K Bachhawat
Feb 1, 1981·Archives of Biochemistry and Biophysics·P GhoshA Surolia
Dec 14, 1978·Biochemical and Biophysical Research Communications·V P TorchilinV N Smirnov
Jan 14, 1983·Biochemical and Biophysical Research Communications·F C Szoka, E Mayhew
Apr 1, 1982·Journal of Pharmaceutical Sciences·K J WidderB Sears
Jun 30, 1988·Biochemical and Biophysical Research Communications·F Umezawa, Y Eto
Mar 29, 2001·Progress in Lipid Research·G L Scherphof, J A Kamps
Sep 6, 1978·Biochimica Et Biophysica Acta·D HoekstraG Scherphof

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