PMID: 3756544Jul 1, 1986Paper

Monosodium glutamate neurotoxicity: a sex-specific impairment of blood pressure but not vasopressin in developing rats

Brain Research Bulletin
R W CloughC D Sladek

Abstract

Neonatal administration of monosodium glutamate (MSG) results in severe adenohypophyseal endocrine malfunction as a result of hypothalamic neurotoxic lesioning. The present study examined the effects of administration of MSG on the neurohypophyseal vasopressinergic (AVP) system and systolic blood pressure (SBP) in adulthood. Monosodium glutamate or hypertonic sodium chloride was administered to male and female rat pups on days 1, 3, 5, 7 and 9 after birth. MSG treatment produced several features characteristic of the MSG-toxicity syndrome, including obesity, anterior pituitary dysgenesis and hypogonadism. However, MSG did not alter neurohypophyseal AVP profiles: AVP content of the posterior pituitary and microdissected regions of the hypothalamus and brainstem were similar in MSG-treated and control rats. Furthermore, MSG treatment did not alter water intake, serum AVP concentration, or the ability to reduce urine output in response to water deprivation. Thus, despite insult to adenohypophyseal function by neonatal administration of MSG, the neurohypophyseal AVP system remained functionally intact. In contrast, neonatal treatment with MSG altered SBP in a sex dependent manner. Female MSG-treated rats, unlike male MSG-treated ra...Continue Reading

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Dec 11, 1999·Pharmacology, Biochemistry, and Behavior·M DubovickýD Jezová
Jan 1, 1989·Chemico-biological Interactions·W K LiuN K Mak
May 5, 2012·Metabolism: Clinical and Experimental·Marlusa Karlen-AmaranteMarli Cardoso Martins-Pinge
Oct 13, 2006·Nature Reviews. Genetics·Allen W Cowley
Oct 2, 2019·Frontiers in Neuroscience·Kathleen F HoltonTerry L Davidson

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