Monosomy 9q and trisomy 16q in a case of congenital solitary infantile myofibromatosis

Virchows Archiv : an International Journal of Pathology
Nicolas SirventFlorence Pedeutour

Abstract

Although infantile myofibromatosis (IM) is the most common fibrous proliferation of infancy, many aspects of this benign lesion have not been explored. IM histogenesis is still poorly understood, despite immunohistochemical staining and ultrastructural features that suggest a myofibroblastic origin. IM diagnosis is often made difficult by the predominance of small primitive spindle cells over myofibroblasts and the presence of intravascular growth. Genetic information is scarce, with only one karyotyped case. Here we describe a case of solitary IM discovered at birth in an otherwise healthy girl. The tumor was well circumscribed, arranged in nodules and made up of ovoid cells without atypia, in a myxoid background. Immunohistochemical evaluation indicated a myofibroblastic differentiation. The cytogenetic and fluorescence in situ hybridization analyses revealed an abnormal chromosome 9, derived from an unbalanced whole-arm translocation between chromosomes 9 and 16. On both chromosomes, the breakpoints were located in the pericentric heterochromatic region. This clonal abnormality has not been reported in other tumors and is different from the chromosome 6q deletion reported in the single previous reported IM karyotype.

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Citations

Feb 1, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Paolo MerciadriArmando Cama
May 12, 2005·International Journal of Pediatric Otorhinolaryngology·Christine B Franzese, Jeffrey Carron
Feb 28, 2008·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Patti Schurr, Wendy Moulsdale
Jul 17, 2010·Cancer Genetics and Cytogenetics·Elisa TassanoCristina Morerio
Apr 14, 2009·Annales de dermatologie et de vénéréologie·E PuzenatF Aubin
Jan 26, 2007·Advances in Dermatology·Mark R Matthews, Clay J Cockerell
Jun 5, 2014·Journal of the American Academy of Dermatology·Jacob MashiahChristine Bodemer
Jun 14, 2008·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Nicoleta C ArvaTibor Valyi-Nagy
Nov 22, 2016·Journal of Cutaneous Pathology·Jeffrey K Mito, Vickie Y Jo

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