Monosynaptic cortical input and local axon collaterals of identified striatonigral neurons. A light and electron microscopic study using the Golgi-peroxidase transport-degeneration procedure

The Journal of Comparative Neurology
P SomogyiA D Smith

Abstract

Following the injection of horseradish peroxidase into the ipsilateral substantia nigra, 36 retrogradely labelled neurons in the striatum were characterized (in three rats) by Golgi staining and gold toning: each neuron was of the medium-size, densely spinous type. Prior to the injection of horseradish peroxidase, two of the rats had had lesions placed in the ipsilateral motor cortex, the third rat had had a lesion placed in the ipsilateral frontal and prefrontal cortex. In the electron microscope, degenerating boutons of cortical neurons were found in asymmetrical synaptic contact with the spines of proximal and distal dendrites of all six of the identified striatonigral neurons that were studied. Some of the degenerating boutons were small (diameter 0.1-0.3 micron), while others were larger (1-2 microns). An individual dendrite of a striatonigral neuron was in symaptic contact with very few degenerating boutons. Local axon collaterals in the striatum could be traced from two of the identified striatonigral neurons that received degenerating cortical boutons. These were studied in the electron microscope; their boutons formed symmetrical synapses with spines or dendritic shafts of other striatal neurons. The synaptic boutons c...Continue Reading

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