Abstract
Metabolic syndrome belongs to the most important risk factors of cardiovascular diseases. The aim of this study was to investigate changes in cardiovascular system induced by high cholesterol and high fat diet (HCHF) in HTG rats and their influence by a pyridoindole antioxidant - SMe1EC2 (S). The effects of S were compared with those of atorvastatin (A). Male HTG rats were fed HCHF (1% cholesterol + 7.5% lard) for 4 weeks. S and A were administered p.o., 50 mg/kg b.w. Following experimental groups were used: Wistar rats (W), hypertriglyceridemic rats (HTG), HTG rats fed HCHF (CHOL), HTG+S (S-HTG), CHOL+S (S-CHOL), and CHOL+A (A-CHOL). Values of blood pressure (BP) and selected ECG parameters were monitored in conscious animals, functions of the isolated heart and aorta were analyzed ex vivo. At the end of the experiment, systolic (sBP) and diastolic (dBP) blood pressure was increased in HTG and CHOL. S and A decreased BP in all treated groups. Accordingly with BP changes, the aortic endothelial function of CHOL was damaged. Both S and A administration ameliorated the endothelium-dependent relaxation to values of W. PQ and QTc intervals were prolonged in CHOL, while the treatment with S or A improved ECG findings. Prodysrhythmog...Continue Reading
References
May 1, 1991·Circulation Research·Y Kihara, J P Morgan
Nov 1, 1990·Circulation Research·J C MerillatT Guarnieri
Dec 1, 1989·Circulation·M LuuJ Walden
Jul 1, 1984·Circulation·M A AllessieJ Hollen
Apr 1, 1997·Journal of Molecular and Cellular Cardiology·T SimorG A Elgavish
Aug 15, 2001·Circulation·X JouvenP Ducimetière
Apr 12, 2005·Basic Research in Cardiology·E F du ToitA Lochner
May 18, 2006·Cellular and Molecular Neurobiology·S StolcS Stvrtina
Feb 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Scott M Grundy
Oct 18, 2011·Pharmacological Reports : PR·Zuzana Broskova, Vladimir Knezl
Apr 24, 2012·Journal of Electrocardiology·Ljuba BacharovaMartin Gajdos
Sep 12, 2012·American Journal of Therapeutics·Philip J Dougherty, Rohit R Arora
Jan 22, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Janice V HuangGregory G Schwartz
Jun 22, 2013·Clinical Cardiology·Marijana TadicCesare Cuspidi
Jul 16, 2013·Experimental Physiology·I WensleyE F du Toit
Aug 28, 2014·Expert Review of Cardiovascular Therapy·Benoit PlourdePaul Poirier
Nov 2, 2014·Lipids in Health and Disease·Wei-Li ZhangZhi-Peng Zou
Mar 30, 2016·European Journal of Clinical Pharmacology·David NiedrigStefan Russmann
Jun 29, 2016·Pharmacological Reports : PR·Fabiana Vieira SimõesDalton Valentim Vassallo
Feb 6, 2017·BMC Complementary and Alternative Medicine·Claudia A ReuleChristiane Schoen
Oct 25, 2017·Bratislavské lekárske listy·B LiptakZ Gasparova