Monotherapy with a novel intervenolin derivative, AS-1934, is an effective treatment for Helicobacter pylori infection

Helicobacter
Tomokazu OhishiManabu Kawada

Abstract

Helicobacter pylori (H. pylori) infection causes various gastrointestinal diseases including gastric cancer. Hence, eradication of this infection could prevent these diseases. The most popular first-line treatment protocol to eradicate H. pylori is termed "triple therapy" and consists of a proton pump inhibitor (PPI), clarithromycin, and amoxicillin or metronidazole. However, the antibiotics used to treat H. pylori infection are hindered by the antibiotics-resistant bacteria and by their antimicrobial activity against intestinal bacteria, leading to side effects. Therefore, an alternative treatment with fewer adverse side effects is urgently required to improve the overall eradication rate of H. pylori. The aim of this study was to assess the effectiveness and mechanism of action of an antitumor agent, intervenolin, and its derivatives as an agent for the treatment of H. pylori infection. We demonstrate that intervenolin, and its derivatives showed selective anti-H. pylori activity, including antibiotic-resistant strains, without any effect on intestinal bacteria. We showed that dihydroorotate dehydrogenase, a key enzyme for de novo pyrimidine biosynthesis, is a target and treatment with intervenolin or its derivatives decrease...Continue Reading

References

May 1, 1992·Infection and Immunity·E D SegalL S Tompkins
Apr 1, 1992·Journal of Clinical Pathology·K Kobashi
Oct 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M L GraysonR C Moellering
Aug 1, 1986·Journal of Medicinal Chemistry·P LindbergB Wallmark
Nov 1, 1996·Infection and Immunity·M KaritaM J Blaser
Aug 12, 2000·The Journal of Biological Chemistry·R A CopelandF Hobbs
Mar 21, 2002·Nature Reviews. Cancer·Richard M Peek, Martin J Blaser
May 22, 2002·The Journal of Biological Chemistry·Manabu KawadaTomio Takeuchi
Apr 12, 2003·Pharmacotherapy·Elaine Chong, Mary H H Ensom
Jul 19, 2006·Clinical Microbiology Reviews·Johannes G KustersErnst J Kuipers
Feb 27, 2007·Journal of Gastroenterology·Hidekazu SuzukiBarry James Marshall
Dec 6, 2011·Journal of Molecular Modeling·Homa AzizianMassoud Amanlou
Oct 3, 2012·Clinical and Experimental Gastroenterology·Riccardo UrgesiMaria Elena Riccioni
Nov 28, 2012·World Journal of Gastroenterology : WJG·Yi-Qi DuZhao-Shen Li
Jan 22, 2013·Expert Opinion on Pharmacotherapy·Sotirios D GeorgopoulosStylianos Karatapanis
Feb 8, 2013·Journal of Clinical Gastroenterology·Nimish Vakil, Dino Vaira
Apr 19, 2013·Organic Letters·Hikaru AbeMasakatsu Shibasaki
May 24, 2013·Clinical Pharmacology and Therapeutics·S A ScottUNKNOWN Clinical Pharmacogenetics Implementation Consortium
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Nov 26, 2014·Proceedings of the National Academy of Sciences of the United States of America·Soracha ThamphiwatanaLiangfang Zhang
Apr 10, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhammad Miftahussurur, Yoshio Yamaoka
Nov 2, 2016·Gut·P MalfertheinerUNKNOWN European Helicobacter and Microbiota Study Group and Consensus panel
Jan 11, 2017·The American Journal of Gastroenterology·William D CheySteven F Moss
Nov 17, 2017·European Journal of Clinical Investigation·Rocco Maurizio ZagariFranco Bazzoli

❮ Previous
Next ❯

Citations

Sep 12, 2018·Helicobacter·Neil R O'MorainColm A O'Morain
Aug 23, 2019·Current Opinion in Gastroenterology·Erick A Argueta, Steven F Moss
Mar 9, 2019·Journal of Cellular Physiology·Abdolmajid GhasemianSeyede Amene Mirforughi
Aug 26, 2020·International Journal of Molecular Sciences·Tomokazu OhishiManabu Kawada
Jun 25, 2021·The Journal of Antibiotics·Manabu KawadaTomokazu Ohishi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Takahisa FurutaKyoichi Ohashi
Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva
M Castro-FernándezM Romero-Gómez
© 2022 Meta ULC. All rights reserved