Monothiol CGFS glutaredoxins and BolA-like proteins: [2Fe-2S] binding partners in iron homeostasis.

Biochemistry
Haoran Li, Caryn E Outten

Abstract

Monothiol glutaredoxins (Grxs) with a signature CGFS active site and BolA-like proteins have recently emerged as novel players in iron homeostasis. Elegant genetic and biochemical studies examining the functional and physical interactions of CGFS Grxs in the fungi Saccharomyces cerevisiae and Schizosaccharomyces pombe have unveiled their essential roles in intracellular iron signaling, iron trafficking, and the maturation of Fe-S cluster proteins. Biophysical and biochemical analyses of the [2Fe-2S] bridging interaction between CGFS Grxs and a BolA-like protein in S. cerevisiae provided the first molecular-level understanding of the iron regulation mechanism in this model eukaryote and established the ubiquitous CGFS Grxs and BolA-like proteins as novel Fe-S cluster-binding regulatory partners. Parallel studies focused on Escherichia coli and human homologues for CGFS Grxs and BolA-like proteins have supported the studies in yeast and provided additional clues about their involvement in cellular iron metabolism. Herein, we review recent progress in uncovering the cellular and molecular mechanisms by which CGFS Grxs and BolA-like proteins help regulate iron metabolism in both eukaryotic and prokaryotic organisms.

References

Jan 18, 1994·Biochemistry·H A DaileyM K Johnson
Nov 1, 1996·European Journal of Biochemistry·M G Claros, P Vincens
May 19, 1998·Trends in Biochemical Sciences·C Askwith, J Kaplan
Oct 24, 2001·The Journal of Biological Chemistry·O ProtchenkoC C Philpott
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·J C RutherfordD R Winge
Mar 6, 2002·The Journal of Biological Chemistry·Yuko Yamaguchi-IwaiRyuzo Sasaki
Feb 8, 2003·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Jeane De FreitasChris Vulpe
May 6, 2003·The Journal of Biological Chemistry·Jordi TamaritJoaquim Ros
May 21, 2003·The Journal of Biological Chemistry·Julian C RutherfordDennis R Winge
Nov 8, 2003·Science·L GiotJ M Rothberg
Dec 12, 2003·The Journal of Biological Chemistry·Sadri ZnaidiSimon Labbé
Jan 10, 2004·Antioxidants & Redox Signaling·Aristi Potamitou Fernandes, Arne Holmgren
Jan 14, 2004·Protein Science : a Publication of the Protein Society·Takuma KasaiShigeyuki Yokoyama
Apr 24, 2004·Annals of the New York Academy of Sciences·Xueying XuZ Leah Harris
Oct 1, 2004·The Journal of Biological Chemistry·María Micaela MolinaEnrique Herrero
Feb 3, 2005·Genetics·Edo KussellStanislas Leibler
Mar 31, 2005·Biochemical and Biophysical Research Communications·Woo-Hyun ChungJung-Hye Roe
Apr 19, 2005·The Journal of Biological Chemistry·Aristi Potamitou FernandesAlexios Vlamis-Gardikas
May 4, 2005·The Journal of Biological Chemistry·Benoit PelletierSimon Labbé
Aug 20, 2005·Nature·Rebecca A WingertUNKNOWN Tübingen 2000 Screen Consortium
Mar 24, 2006·Nature·Nevan J KroganJack F Greenblatt
May 9, 2006·Antioxidants & Redox Signaling·Raffaele LodiAnthony H V Schapira
Jul 20, 2006·Nature Chemical Biology·Tracey A Rouault
Sep 8, 2006·Wiener klinische Wochenschrift·Manfred Nairz, Günter Weiss
Nov 1, 2006·Journal of Cell Science·Nuria Pujol-CarrionMaria Angeles de la Torre-Ruiz
Jan 11, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Simon LabbéAlexandre Mercier
Aug 19, 2007·Lancet·Michael B Zimmermann, Richard F Hurrell
Sep 6, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·William J JoChris D Vulpe
Nov 9, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Koichi HasegawaJohji Miwa
Nov 10, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Jacques Meyer

❮ Previous
Next ❯

Citations

Mar 7, 2013·Trends in Plant Science·Gianpiero ViganiJean-François Briat
Jan 8, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Daphne T MapoleloMichael K Johnson
Dec 4, 2012·Antioxidants & Redox Signaling·Michel B ToledanoAeid Igbaria
Jun 5, 2014·PloS One·Jean-François JacquesSimon Labbé
Dec 18, 2013·Brain : a Journal of Neurology·Peter R BakerJohan L K Van Hove
Mar 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Catherine B PoorChuan He
Apr 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Lucia BanciJulia Winkelmann
Aug 21, 2014·Natural Product Reports·Hubertus Haas
Dec 10, 2014·Critical Reviews in Biochemistry and Molecular Biology·Jonathan G Van VrankenJared Rutter
Nov 29, 2015·Journal of the American Chemical Society·Lucia BanciRiccardo Muzzioli
Aug 22, 2013·Current Opinion in Microbiology·Caryn E Outten, Angela-Nadia Albetel
Aug 7, 2013·Current Opinion in Microbiology·Simon LabbéJean-François Jacques
Sep 24, 2014·Biochimica Et Biophysica Acta·Nunziata Maio, Tracey A Rouault
Sep 30, 2014·Biochimica Et Biophysica Acta·Jérémy CouturierNicolas Rouhier
Dec 3, 2014·Biochimica Et Biophysica Acta·Erin L Mettert, Patricia J Kiley
Jun 19, 2013·Molecular Systems Biology·Jeffrey M SkerkerAdam P Arkin
Aug 25, 2015·Nature Chemical Biology·Lucia BanciJulia Winkelmann
Aug 25, 2015·Biochemical and Biophysical Research Communications·Haiyan XiaKuanyu Li
Jun 28, 2015·European Journal of Cell Biology·Ulrich MühlenhoffRoland Lill
Jan 28, 2014·Biochimie·Oliver StehlingRoland Lill
Jan 28, 2014·Current Opinion in Chemical Biology·Daniel W Bak, Sean J Elliott
Feb 12, 2013·Biochimica Et Biophysica Acta·Bruno MantaRafael Radi
May 16, 2015·Free Radical Biology & Medicine·Khanh PhamNinghui Cheng
Nov 10, 2013·Molecular Plant·Jérémy CouturierNicolas Rouhier
Mar 7, 2015·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·R PieperA Bondzio
Jun 13, 2013·Biochemical and Biophysical Research Communications·Lars BräutigamCarsten Berndt
Apr 30, 2016·The Science of the Total Environment·Sidhartha PattanaikGerald P Huffman
Jun 11, 2016·The FEBS Journal·Michal Eisenberg-Bord, Maya Schuldiner
Jul 23, 2016·Biochemical and Biophysical Research Communications·Hyo-Jin KimJung-Hye Roe
Sep 4, 2016·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Insiya FidaiJ A Cowan
Oct 8, 2016·Metallomics : Integrated Biometal Science·N Maio, T A Rouault
Mar 18, 2017·Antioxidants & Redox Signaling·Pete ChandrangsuJohn D Helmann
Jul 21, 2017·Metallomics : Integrated Biometal Science·Adrienne C DlouhyCaryn E Outten
Jan 20, 2018·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Jonathan Przybyla-ToscanoNicolas Rouhier
Apr 29, 2018·Applied Microbiology and Biotechnology·Long-Bin Zhang, Ming-Guang Feng
Oct 24, 2017·Metallomics : Integrated Biometal Science·Amanda T VoDeborah L Perlstein
Jun 21, 2018·Metallomics : Integrated Biometal Science·Huanhuan Lv, Peng Shang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.