Monozygotic triplets with Crohn's disease of the colon

Gastroenterology
J PurrmannG Strohmeyer

Abstract

Female monozygotic triplets all developed Crohn's disease within a period of 11 mo. The monozygosity was demonstrated by analysis of 24 genetic markers of different chromosomal localization. Crohn's disease was diagnosed using clinical, radiologic, and endoscopic findings. Histologic evaluation of bowel tissue was consistent with Crohn's disease. All 3 patients had colon involvement; the terminal ileum appeared normal. The patient in whom Crohn's disease was first diagnosed had the severest course. Our observations support the role of a genetic influence in the manifestation of Crohn's disease. Nevertheless, environmental factors or microorganisms, or both, have to be taken into account, perhaps as factors promoting the outbreak of Crohn's disease.

Citations

Aug 1, 1988·Digestive Diseases and Sciences·A Van GossumJ Wybran
Oct 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·M CastroH B Hadorn
Nov 6, 2001·The American Journal of Gastroenterology·N P BreslinL R Sutherland
May 26, 2004·Best Practice & Research. Clinical Gastroenterology·R K Russell, J Satsangi
Nov 5, 2021·Science China. Life Sciences·Xiaodan LiaoChunli Bai

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